Jean Pyo Lee

TL;DR: Intracranial transplantation of neural stem cells (NSCs) delayed disease onset, preserved motor function, reduced pathology and prolonged survival in a mouse model of Sandhoff disease, a lethal gangliosidosis.

TL;DR: Even the early regional identities of human neurospheres may not be irreversible and may be altered by local inductive cues, and the properties of glial fibrillary acidic protein (GFAP)-, glutamate-, and gamma-aminobutyric acid (GABA)-expressing cells derived from neuro Spheres of the respective CNS regions appear to be regionally and temporally different.

TL;DR: Through the implantation of NSCs into the brains of both neonatal and juvenile/young adult twi mice, it is determined that widespread oligodendrocyte replacement and remyelination is feasible and suggest a number of points regarding cellular therapies against degenerative diseases with a prominent cell non‐autonomous component.

TL;DR: Exposure of primary glial cultures to psychosine induces the expression and the production of matrix metalloproteinase (MMP)‐3 that mediated a morphological transformation of microglia into a multinucleated globoid cell type in GLD.

TL;DR: Data indicate that NB-DGJ alone was more effective in targeting storage in juvenileSD mice than were NSCs alone, and no additive or synergistic effect between NSC and drug was found in these juvenile SD mice.