D
Diego Manni
Researcher at Newcastle University
Publications - 4
Citations - 319
Diego Manni is an academic researcher from Newcastle University. The author has contributed to research in topics: Autophagy & Replication protein A. The author has an hindex of 4, co-authored 4 publications receiving 247 citations.
Papers
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Journal ArticleDOI
Oxidation of SQSTM1/p62 mediates the link between redox state and protein homeostasis.
Bernadette Carroll,Elsje G. Otten,Diego Manni,Rhoda Stefanatos,Fiona M. Menzies,Graham Smith,Diana Jurk,Niall S. Kenneth,Simon Wilkinson,João F. Passos,Johannes Attems,Elizabeth A. Veal,Elisa Teyssou,Danielle Seilhean,Stéphanie Millecamps,Eeva-Liisa Eskelinen,Agnieszka K. Bronowska,David C. Rubinsztein,Alberto Sanz,Viktor I. Korolchuk +19 more
TL;DR: It is proposed that the redox-sensitivity of p62 may have evolved in vertebrates as a mechanism that allows activation of autophagy in response to oxidative stress to maintain cellular homoeostasis and increase cell survival.
Journal ArticleDOI
SQSTM1/p62 mediates crosstalk between autophagy and the UPS in DNA repair
Graeme Hewitt,Bernadette Carroll,Rezazadeh Sarallah,Clara Correia-Melo,Mikolaj Ogrodnik,Glyn Nelson,Elsje G. Otten,Diego Manni,Robin Antrobus,Brian A. Morgan,Thomas von Zglinicki,Diana Jurk,Andrei Seluanov,Vera Gorbunova,Terje Johansen,João F. Passos,Viktor I. Korolchuk +16 more
TL;DR: Nuclear localization of SQSTM1 and its association with DDF increase with aging and are prevented by life-span-extending dietary restriction, suggesting that an imbalance in the mechanism identified here may contribute to aging and age-related diseases.
Journal ArticleDOI
Oxidative Stress by Monoamine Oxidase-A Impairs Transcription Factor EB Activation and Autophagosome Clearance, Leading to Cardiomyocyte Necrosis and Heart Failure
Yohan Santin,Yohan Santin,Pierre Sicard,Pierre Sicard,François Vigneron,François Vigneron,Céline Guilbeau-Frugier,Céline Guilbeau-Frugier,Marianne Dutaur,Marianne Dutaur,Olivier Lairez,Olivier Lairez,Bettina Couderc,Diego Manni,Viktor I. Korolchuk,Frank Lezoualc'h,Frank Lezoualc'h,Angelo Parini,Angelo Parini,Jeanne Mialet-Perez,Jeanne Mialet-Perez +20 more
TL;DR: It is demonstrated that the MAO-A/H2O2 axis has a negative impact on the elimination and recycling of mitochondria through the autophagy-lysosome pathway, which participates in cardiomyocyte death and HF.
Book ChapterDOI
Mitochondrial degradation, autophagy and neurodegenerative disease
TL;DR: The autophagy and mitophagy pathways are described and the key molecular players controlling these processes are highlighted and studies of these pathways not only produce an important insight into the mechanisms of neurodegenerative diseases but also suggest molecular components of mitochondrial quality control which could be used as targets for therapeutic interventions.