J
Jeewon Kim
Researcher at Stanford University
Publications - 23
Citations - 6789
Jeewon Kim is an academic researcher from Stanford University. The author has contributed to research in topics: Metastasis & Cancer. The author has an hindex of 14, co-authored 21 publications receiving 5970 citations. Previous affiliations of Jeewon Kim include University of California, Berkeley & Seoul National University.
Papers
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Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
Journal ArticleDOI
Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data
Marina Sirota,Joel T. Dudley,Joel T. Dudley,Jeewon Kim,Annie P. Chiang,Annie P. Chiang,Alexander A. Morgan,Alexander A. Morgan,Alejandro Sweet-Cordero,Julien Sage,Atul J. Butte,Atul J. Butte +11 more
TL;DR: A systematic computational approach to predict novel therapeutic indications on the basis of comprehensive testing of molecular signatures in drug-disease pairs for repositioning established drugs to treat a wide range of human diseases.
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Promoter of lncRNA Gene PVT1 Is a Tumor-Suppressor DNA Boundary Element
Seung Woo Cho,Jin Xu,Ruping Sun,Maxwell R. Mumbach,Ava C. Carter,Y. Grace Chen,Kathryn E. Yost,Jeewon Kim,Jing He,Stephanie A. Nevins,Suet-Feung Chin,Carlos Caldas,Carlos Caldas,S. John Liu,Max A. Horlbeck,Daniel A. Lim,Daniel A. Lim,Jonathan S. Weissman,Christina Curtis,Howard Y. Chang +19 more
TL;DR: It is shown that the PVT1 promoter has a tumor-suppressor function that is independent of PVT 1 lnc RNA, and regulatory sequences of lncRNA genes as potential disease-associated DNA elements are highlighted.
Journal ArticleDOI
N6-Methyladenosine Modification Controls Circular RNA Immunity
Y. Grace Chen,Y. Grace Chen,Robert Chen,Sadeem Ahmad,Sadeem Ahmad,Rohit Verma,Sudhir Pai Kasturi,Laura Amaya,James P. Broughton,Jeewon Kim,Cristhian Cadena,Cristhian Cadena,Bali Pulendran,Sun Hur,Sun Hur,Howard Y. Chang,Howard Y. Chang +16 more
TL;DR: It is shown that N6-methyladenosine (m6A) RNA modification on human circRNAs inhibits innate immunity, and m6A modification abrogates immune gene activation and adjuvant activity.
Journal ArticleDOI
Measurement in vivo of proliferation rates of slow turnover cells by 2H2O labeling of the deoxyribose moiety of DNA.
Richard A. Neese,Lisa M. Misell,Scott M. Turner,A. Chu,Jeewon Kim,Denise Cesar,R. Hoh,Fernando Antelo,A. Strawford,Joseph M. McCune,M. Christiansen,Marc K. Hellerstein +11 more
TL;DR: 2H2O labeling of dR in DNA allows safe, convenient, reproducible, and inexpensive measurement of cell proliferation in humans and experimental animals and is well suited for slow turnover cells.