J
Jeffrey Thomas
Researcher at Millennium Pharmaceuticals
Publications - 11
Citations - 7459
Jeffrey Thomas is an academic researcher from Millennium Pharmaceuticals. The author has contributed to research in topics: Gene & Chromosome 4. The author has an hindex of 7, co-authored 9 publications receiving 5829 citations.
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Journal ArticleDOI
The Genotype-Tissue Expression (GTEx) project
John T. Lonsdale,Jeffrey Thomas,Mike Salvatore,Rebecca Phillips,Edmund Lo,Saboor Shad,Richard Hasz,Gary Walters,Fernando U. Garcia,Nancy Young,Barbara A. Foster,Mike Moser,Ellen Karasik,Bryan Gillard,Kimberley Ramsey,Susan L. Sullivan,Jason Bridge,Harold Magazine,John Syron,Johnelle Fleming,Laura A. Siminoff,Heather M. Traino,Maghboeba Mosavel,Laura Barker,Scott D. Jewell,Daniel C. Rohrer,Dan Maxim,Dana Filkins,Philip Harbach,Eddie Cortadillo,Bree Berghuis,Lisa Turner,Eric Hudson,Kristin Feenstra,Leslie H. Sobin,James A. Robb,Phillip Branton,Greg E. Korzeniewski,Charles Shive,David Tabor,Liqun Qi,Kevin Groch,Sreenath Nampally,Steve Buia,Angela Zimmerman,Anna M. Smith,Robin Burges,Karna Robinson,Kim Valentino,Deborah Bradbury,Mark Cosentino,Norma Diaz-Mayoral,Mary Kennedy,Theresa Engel,Penelope Williams,Kenyon Erickson,Kristin G. Ardlie,Wendy Winckler,Gad Getz,Gad Getz,David S. DeLuca,MacArthur Daniel MacArthur,MacArthur Daniel MacArthur,Manolis Kellis,Alexander Thomson,Taylor Young,Ellen Gelfand,Molly Donovan,Yan Meng,George B. Grant,Deborah C. Mash,Yvonne Marcus,Margaret J. Basile,Jun Liu,Jun Zhu,Zhidong Tu,Nancy J. Cox,Dan L. Nicolae,Eric R. Gamazon,Hae Kyung Im,Anuar Konkashbaev,Jonathan K. Pritchard,Jonathan K. Pritchard,Matthew Stevens,Timothée Flutre,Xiaoquan Wen,Emmanouil T. Dermitzakis,Tuuli Lappalainen,Roderic Guigó,Jean Monlong,Michael Sammeth,Daphne Koller,Alexis Battle,Sara Mostafavi,Mark I. McCarthy,Manual Rivas,Julian Maller,Ivan Rusyn,Andrew B. Nobel,Fred A. Wright,Andrey A. Shabalin,Mike Feolo,Nataliya Sharopova,Anne Sturcke,Justin Paschal,James M. Anderson,Elizabeth L. Wilder,Leslie Derr,Eric D. Green,Jeffery P. Struewing,Gary F. Temple,Simona Volpi,Joy T. Boyer,Elizabeth J. Thomson,Mark S. Guyer,Cathy Ng,Assya Abdallah,Deborah Colantuoni,Thomas R. Insel,Susan E. Koester,Roger Little,Patrick Bender,Thomas Lehner,Yin Yao,Carolyn C. Compton,Jimmie B. Vaught,Sherilyn Sawyer,Nicole C. Lockhart,Joanne P. Demchok,Helen F. Moore +129 more
TL;DR: The Genotype-Tissue Expression (GTEx) project is described, which will establish a resource database and associated tissue bank for the scientific community to study the relationship between genetic variation and gene expression in human tissues.
Journal ArticleDOI
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families.
Melanie M. Mahtani,Elisabeth Widén,Elisabeth Widén,M Lehto,Jeffrey Thomas,Mark I. McCarthy,James Brayer,Barbara M. Bryant,Gayun Chan,Mark J. Daly,Carol Forsblom,T Kanninen,Andrew Kirby,Leonid Kruglyak,Kevin Munnelly,M. Parkkonen,Mary Pat Reeve-Daly,Alix Weaver,Thomas Brettin,Geoffrey M. Duyk,Eric S. Lander,Leif Groop +21 more
TL;DR: It is suggested that NIDDM2 and MODY3 may represent different alleles of the same gene, and the existence of a gene NidDM2 causing NID DM associated with low insulin secretion is inferred.
Journal ArticleDOI
Characterization of the MODY3 phenotype. Early-onset diabetes caused by an insulin secretion defect.
M. Lehto,Tiinamaija Tuomi,Melanie M. Mahtani,E. Widen,Carol Forsblom,L Sarelin,M Gullstrom,B Isomaa,Mikko Lehtovirta,A Hyrkkö,T Kanninen,Marju Orho,Susan E. Manley,R C Turner,Thomas Brettin,Andrew Kirby,Jeffrey Thomas,Geoffrey M. Duyk,Eric S. Lander,Marja-Riitta Taskinen,Leif Groop +20 more
TL;DR: It is suggested that mutations at the MODY3/NIDDM2 gene(s) result in a reduced insulin secretory response, that subsequently progresses to diabetes and underlines the importance of subphenotypic classification in studies of diabetes.
Journal ArticleDOI
A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
M. A. Permutt,J. Wasson,Brian K. Suarez,Jennifer Y. Lin,Jeffrey Thomas,Joanne M. Meyer,Steve Lewitzky,Jean S. Rennich,Alex Parker,Laura DuPrat,Sanchit Maruti,Susan D. Chayen,Benjamin Glaser +12 more
TL;DR: Credence is lent to the hypothesis, now supported by four studies of Caucasian populations and most recently by a combined analysis of 1,852 pedigrees, that a type 2 diabetes susceptibility locus resides on chromosome 20q in Ashkenazi Jewish descent.
Journal ArticleDOI
Novel mutations and a mutational hotspot in the MODY3 gene.
M A Glucksmann,M Lehto,O Tayber,S Scotti,L Berkemeier,J C Pulido,Y Wu,W J Nir,L Fang,P Markel,K D Munnelly,J Goranson,M Orho,B M Young,J L Whitacre,C McMenimen,M Wantman,Tiinamaija Tuomi,James H. Warram,Carol Forsblom,Martin Carlsson,J Rosenzweig,G Kennedy,G M Duyk,Jeffrey Thomas +24 more
TL;DR: Mutations in this gene appear to be most strongly associated with early-onset diabetes, and it is proposed that instability of this sequence represents a general mutational mechanism in M0DY3.