J
Jeffrey V. Ravetch
Researcher at Rockefeller University
Publications - 310
Citations - 59480
Jeffrey V. Ravetch is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antibody & Receptor. The author has an hindex of 110, co-authored 296 publications receiving 54829 citations. Previous affiliations of Jeffrey V. Ravetch include Bristol-Myers Squibb & Kettering University.
Papers
More filters
Journal ArticleDOI
Fc-optimized antibodies elicit CD8 immunity to viral respiratory infection
TL;DR: The capacity for IgG antibodies to induce protective adaptive immunity to viral infection when they selectively activate a dendritic cell and T cell pathway is highlighted, with important implications for the development of therapeutic antibodies with improved antiviral efficacy against viral respiratory pathogens.
Journal ArticleDOI
A tandemly repeated sequence determines the binding domain for an erythrocyte receptor binding protein of P. falciparum
TL;DR: A repeat domain, a common feature of plasmodial antigens, has been shown to have a function independent of the immune system and is supported by the ability of antibodies directed against the repeat sequence to inhibit the in vitro invasion of erythrocytes by merozoites.
Journal ArticleDOI
Experimental antibody therapy of liver metastases reveals functional redundancy between Fc gammaRI and Fc gammaRIV.
Marielle A. Otten,Marielle A. Otten,Gerben J. van der Bij,Sjef Verbeek,Falk Nimmerjahn,Jeffrey V. Ravetch,Robert H. J. Beelen,Jan G. J. van de Winkel,Jan G. J. van de Winkel,Marjolein van Egmond +9 more
TL;DR: Since Ab treatment almost completely prevented development of liver metastases, postoperative adjuvant Ab therapy may help to improve patient prognosis and support that Kupffer cells are involved as effector cells.
Journal Article
Disruption of Cell-Cell Adhesion Enhances Antibody-dependent Cellular Cytotoxicity: Implications for Antibody-based Therapeutics of Cancer
TL;DR: The novel ability of an antiadhesive antibody, targeted at the potent homophilic cell adhesion molecule E-cadherin, to play a dual role as participant in, and sensitizing agent for, host immune-mediated antitumor activity is demonstrated.
Journal Article
Amplified follicular immune complex deposition in mice lacking the Fc receptor gamma-chain does not alter maturation of the B cell response.
TL;DR: In this article, the role of Ag-Ab complexes in the regulation of the maturation of the B cell immune response was investigated in mice perturbed in the deposition and retention of such complexes.