J
Jeffrey V. Ravetch
Researcher at Rockefeller University
Publications - 310
Citations - 59480
Jeffrey V. Ravetch is an academic researcher from Rockefeller University. The author has contributed to research in topics: Antibody & Receptor. The author has an hindex of 110, co-authored 296 publications receiving 54829 citations. Previous affiliations of Jeffrey V. Ravetch include Bristol-Myers Squibb & Kettering University.
Papers
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Journal ArticleDOI
FcγRIII (CD16) on human macrophages is a functional product of the FcγRIII-2 gene
Bice Perussia,Jeffrey V. Ravetch +1 more
TL;DR: FcγRIII (CD16) on cultured monocytes is insensitive to phosphatidylinositol‐specific phospholipase C, is not allelic for the neutrophil NA alloantigens NA‐1/NA‐2, and functions to trigger cytotoxicity upon ligand binding.
Journal ArticleDOI
DC subset-specific induction of T cell responses upon antigen uptake via Fcγ receptors in vivo.
Christian H. K. Lehmann,Anna Baranska,Anna Baranska,Gordon F. Heidkamp,Lukas Heger,Kirsten Neubert,Jennifer J. Lühr,Alana Hoffmann,Katharina C. Reimer,Christin Brückner,Simone Beck,Michaela Seeling,Melissa Kießling,Didier Soulat,Anne Krug,Jeffrey V. Ravetch,Jeanette H. W. Leusen,Falk Nimmerjahn,Diana Dudziak +18 more
TL;DR: It is shown that antigen uptake under steady-state conditions results in a short-term expansion of antigen-specific T cells, whereas under inflammatory conditions especially, the activating Fc&ggr;RIV is able to induce superior CD4+ and CD8+ T cell responses.
Patent
Mice mutant for functional Fc receptors and method of treating autoimmune diseases
TL;DR: In this article, a non-naturally occurring non-human vertebrate animal incapable of expressing a functional Fc receptor which may optionally be expressing a protein which comprises a domain of a human Fc-RBP, as well as DNA encoding such Fc RBP-based proteins is described.
Journal ArticleDOI
Differential contribution of the FcRγ chain to the surface expression of the T cell receptor among T cells localized in epithelia: analysis of FcRγ‐deficient mice
Seung Yong Park,Hisashi Arase,Keisuke Wakizaka,Nakami Hirayama,Shigehiro Masaki,Soichiro Sato,Jeffrey V. Ravetch,Takashi Saito +7 more
TL;DR: Results indicate that the FcRγ chain contributes differently to the TCR expression and to the development of T cells localized in epithelia.
Journal ArticleDOI
Anti-retroviral antibody FcγR-mediated effector functions.
TL;DR: This review focuses on recent studies on broadly neutralizing anti‐HIV‐1 antibodies that revealed that Fc‐FcγR interactions are required to achieve full therapeutic activity through clearance of IgG‐opsonized virions and elimination of HIV‐infected cells.