Jeffrey V. Ravetch

TL;DR: The results suggest that Ssp-3-bearing molecules participate in the process of parasite internalization.

TL;DR: Observations suggest cross talk between two immunoinhibitory receptors, FcγRIIB and PD-1, on the regulation of autoimmune diseases.

TL;DR: Examination of different T cell populations reveals that ζ/η and Fcγ have distinct expression patterns that correlate with their thymus dependency, suggesting that a possible function for the differential expression of ζ family proteins may be to impart distinctive signaling properties to TCR complexes expressed on specific Tcell populations.

TL;DR: In this article, the authors present reagents, methods and systems for predicting the cytotoxic activity of an antibody or variant thereof comprising: determining a binding affinity of the antibody or a variant thereof to a Fc activating receptor; determining abinding affinity of a variant of the same antibody to an Fc inhibitory receptor; and calculating the ratio of said activating binding affinity to said inhibitory binding affinity (A/I ratio).

TL;DR: In this paper, the authors examined the Fab and Fc structures of anti-DENV antibodies from patients before and after infection and with variable disease outcomes and found that DENV infection induced a specific increase in immunoglobulin G1 (IgG1) afucosylation, and the levels of afucosity were predictive of dengue disease severity.