Jennifer Antonchuk

TL;DR: It is demonstrated that thrombopoietin (THPO) and its receptor, MPL, are critically involved in postnatal steady-state HSC maintenance, reflected in a 150-fold reduction of HSCs in adult Thpo(-/-) mice.

TL;DR: In this study, HSC regulation in White Spotting 41 (KitW41/W41) mice is investigated, with a partial loss of function of Kit, and accelerated in vivo BrdU incorporation and cell cycle kinetics implicated a previously unrecognized role of Kit in maintaining quiescent HSCs in steady state adult hematopoiesis.

TL;DR: This screen demonstrates the utility of large-scale N-ethyl-N-nitrosourea mutagenesis suppressor screens in mice for the simultaneous discovery and in vivo validation of targets for therapeutic discovery in diseases for which mouse models are available.

TL;DR: This work identifies thrombopoietin (THPO) and the cytokine signaling inhibitor LNK, as opposing physiological regulators of HSC expansion, which is highly selective for self-renewing long-term HSCs (LT-HSCs), which show enhanced THPO responsiveness.

TL;DR: Two hypomorphic alleles of mouse Pgm3 are described and there are specific physiological consequences of a graded reduction in Pgm2 activity and global UDP-GlcNAc levels, suggesting that while universally required, the functions of certain proteins and, as a consequence, certain cell types are especially sensitive to reductions in PGM3 activity.