N
Natalija Buza-Vidas
Researcher at John Radcliffe Hospital
Publications - 35
Citations - 4356
Natalija Buza-Vidas is an academic researcher from John Radcliffe Hospital. The author has contributed to research in topics: Progenitor cell & Stem cell. The author has an hindex of 26, co-authored 35 publications receiving 4081 citations. Previous affiliations of Natalija Buza-Vidas include University of Oxford & Medical Research Council.
Papers
More filters
Journal ArticleDOI
Identification of Flt3(+) lympho-myeloid stem cells lacking erythro-megakaryocytic potential: A revised road map for adult blood lineage commitment
Jörgen Adolfsson,Robert Månsson,Natalija Buza-Vidas,Anne Hultquist,Karina Liuba,Christina Jensen,David Bryder,Liping Yang,O J Borge,Lina Thorén,Kristina Anderson,Ewa Sitnicka,Yutaka Sasaki,Mikael Sigvardsson,Sten Eirik W. Jacobsen +14 more
TL;DR: Evidence is presented for a population of cells which, although sustaining a high proliferative and combined lympho-myeloid differentiation potential, have lost the ability to adopt erythroid and megakaryocyte lineage fates.
Journal ArticleDOI
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem Cells
Hong Qian,Natalija Buza-Vidas,Natalija Buza-Vidas,Craig D. Hyland,Christina Jensen,Christina Jensen,Jennifer Antonchuk,Robert Månsson,Lina Thorén,Marja Ekblom,Warren S. Alexander,Sten Eirik W. Jacobsen,Sten Eirik W. Jacobsen +12 more
TL;DR: It is demonstrated that thrombopoietin (THPO) and its receptor, MPL, are critically involved in postnatal steady-state HSC maintenance, reflected in a 150-fold reduction of HSCs in adult Thpo(-/-) mice.
Journal ArticleDOI
Molecular Evidence for Hierarchical Transcriptional Lineage Priming in Fetal and Adult Stem Cells and Multipotent Progenitors
Robert Månsson,Anne Hultquist,Sidinh Luc,Liping Yang,Kristina Anderson,Shabnam Kharazi,Suleiman Al-Hashmi,Karina Liuba,Lina Thorén,Jörgen Adolfsson,Natalija Buza-Vidas,Hong Qian,Shamit Soneji,Tariq Enver,Mikael Sigvardsson,Sten Eirik W. Jacobsen +15 more
TL;DR: Global and single-cell analyses revealed a hierarchical organization of transcriptional lineage programs, with downregulation of megakaryocyte-erythroid genes from HSCs to LMPPs, sustained granulocyte-monocyte priming, and upregulation of common lymphoid (but not B and T cell-specific) genes.
Journal ArticleDOI
Key Role of flt3 Ligand in Regulation of the Common Lymphoid Progenitor but Not in Maintenance of the Hematopoietic Stem Cell Pool.
Ewa Sitnicka,David Bryder,Kim Theilgaard-Mönch,Natalija Buza-Vidas,Jörgen Adolfsson,Sten Eirik W. Jacobsen +5 more
TL;DR: Adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.
Journal ArticleDOI
Persistent malignant stem cells in del(5q) myelodysplasia in remission.
Ramin Tehranchi,Petter S. Woll,Kristina Anderson,Natalija Buza-Vidas,Takuo Mizukami,Adam J. Mead,Ingbritt Åstrand-Grundström,Bodil Strömbeck,Andrea Horvat,Helen Ferry,Rakesh Singh Dhanda,Robert Hast,Tobias Rydén,Paresh Vyas,Gudrun Göhring,Brigitte Schlegelberger,Bertil Johansson,Eva Hellström-Lindberg,Alan F. List,Lennart Nilsson,Sten Eirik W. Jacobsen +20 more
TL;DR: Rare and phenotypically distinct del(5q) myelodysplastic syndrome stem cells were identified that were also selectively resistant to therapeutic targeting at the time of complete clinical and cytogenetic remission.