C
Carolyn A. de Graaf
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 38
Citations - 2453
Carolyn A. de Graaf is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Haematopoiesis & Stem cell. The author has an hindex of 19, co-authored 36 publications receiving 2012 citations. Previous affiliations of Carolyn A. de Graaf include Netherlands Cancer Institute & University of Melbourne.
Papers
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Journal ArticleDOI
Genome-wide Maps of Nuclear Lamina Interactions in Single Human Cells
Jop Kind,Jop Kind,Ludo Pagie,Sandra S. de Vries,Leila Nahidiazar,Siddharth S. Dey,Magda Bienko,Ye Zhan,Bryan R. Lajoie,Carolyn A. de Graaf,Mario Amendola,Geoffrey Fudenberg,Maxim Imakaev,Leonid A. Mirny,Kees Jalink,Job Dekker,Alexander van Oudenaarden,Bas van Steensel +17 more
TL;DR: The consistency of NL contacts is inversely linked to gene activity in single cells and correlates positively with the heterochromatic histone modification H3K9me3, which highlights fundamental principles of single-cell chromatin organization.
Journal ArticleDOI
Platelets kill intraerythrocytic malarial parasites and mediate survival to infection
Brendan J. McMorran,Vikki M. Marshall,Carolyn A. de Graaf,Carolyn A. de Graaf,Karen E. Drysdale,Meriam Shabbar,Gordon K. Smyth,Jason Corbin,Warren S. Alexander,Simon J. Foote +9 more
TL;DR: Results indicate a protective function for platelets in the early stages of erythrocytic infection distinct from their role in cerebral malaria.
Journal ArticleDOI
The transcription factor Erg is essential for definitive hematopoiesis and the function of adult hematopoietic stem cells.
Stephen J. Loughran,Elizabeth A. Kruse,Elizabeth A. Kruse,Douglas F. Hacking,Douglas F. Hacking,Carolyn A. de Graaf,Carolyn A. de Graaf,Craig D. Hyland,Tracy A. Willson,Katya J. Henley,Sarah Ellis,Anne K. Voss,Donald Metcalf,Douglas J. Hilton,Douglas J. Hilton,Warren S. Alexander,Warren S. Alexander,Benjamin T. Kile,Benjamin T. Kile +18 more
TL;DR: It is shown that Erg is required for definitive hematopoiesis, adult hematOPoietic stem cell function and the maintenance of normal peripheral blood platelet numbers.
Journal ArticleDOI
The Lmo2 Oncogene Initiates Leukemia in Mice by Inducing Thymocyte Self-Renewal
Matthew P. McCormack,Matthew P. McCormack,Lauren F. Young,Sumitha Vasudevan,Carolyn A. de Graaf,Rosalind Codrington,Terence H. Rabbitts,Stephen M. Jane,Stephen M. Jane,David J. Curtis,David J. Curtis +10 more
TL;DR: Lmo2 promotes the self-renewal of preleukemic thymocytes, providing a mechanism by which committed T cells can then accumulate additional genetic mutations required for leukemic transformation.
Journal ArticleDOI
Thrombopoietin and hematopoietic stem cells.
TL;DR: This review will discuss TPO signaling pathways, regulation of T PO levels and the role of TPO in normal hematopoiesis and during myeloproliferative disease.