C
Christopher T. Brown
Researcher at University of California, Berkeley
Publications - 51
Citations - 8272
Christopher T. Brown is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Metagenomics & Genome. The author has an hindex of 28, co-authored 45 publications receiving 6178 citations. Previous affiliations of Christopher T. Brown include University of California, Davis & Planetary Science Institute.
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Journal ArticleDOI
A new view of the tree of life
Laura A. Hug,Laura A. Hug,Brett J. Baker,Karthik Anantharaman,Christopher T. Brown,Alexander J. Probst,Cindy J. Castelle,Cristina N. Butterfield,Alex W Hernsdorf,Yuki Amano,Kotaro Ise,Yohey Suzuki,Natasha Dudek,David A. Relman,David A. Relman,Kari M. Finstad,Ronald Amundson,Brian C. Thomas,Jillian F. Banfield,Jillian F. Banfield +19 more
TL;DR: New genomic data from over 1,000 uncultivated and little known organisms, together with published sequences, are used to infer a dramatically expanded version of the tree of life, with Bacteria, Archaea and Eukarya included.
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dRep: a tool for fast and accurate genomic comparisons that enables improved genome recovery from metagenomes through de-replication
TL;DR: For example, dRep as mentioned in this paper reduces the computational time for pairwise genome comparisons by sequentially applying a fast, inaccurate estimation of genome distance, and a slow, accurate measure of average nucleotide identity.
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Unusual biology across a group comprising more than 15% of domain Bacteria
Christopher T. Brown,Laura A. Hug,Brian C. Thomas,Itai Sharon,Cindy J. Castelle,Andrea Singh,Michael J. Wilkins,Kelly C. Wrighton,Kenneth H. Williams,Jillian F. Banfield +9 more
TL;DR: This work reconstructed 8 complete and 789 draft genomes from bacteria representing >35 phyla and documented features that consistently distinguish these organisms from other bacteria, infer that this group, which may comprise >15% of the bacterial domain, has shared evolutionary history, and describe it as the candidate phyla radiation (CPR).
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Thousands of microbial genomes shed light on interconnected biogeochemical processes in an aquifer system
Karthik Anantharaman,Christopher T. Brown,Laura A. Hug,Itai Sharon,Cindy J. Castelle,Alexander J. Probst,Brian C. Thomas,Andrea Singh,Michael J. Wilkins,Ulas Karaoz,Eoin L. Brodie,Kenneth H. Williams,Susan S. Hubbard,Jillian F. Banfield,Jillian F. Banfield +14 more
TL;DR: Terabase-scale cultivation-independent metagenomics is applied to aquifer sediments and groundwater and 2,540 draft-quality, near-complete and complete strain-resolved genomes are reconstructed, finding that few organisms within the community can conduct multiple sequential redox transformations.
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Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes
Christopher T. Brown,Austin G. Davis-Richardson,Adriana Giongo,Kelsey A. Gano,David B. Crabb,Nabanita Mukherjee,George Casella,Jennifer C. Drew,Jorma Ilonen,Mikael Knip,Heikki Hyöty,Riitta Veijola,Tuula Simell,Olli Simell,Josef Neu,Clive Wasserfall,Desmond A. Schatz,Mark A. Atkinson,Eric W. Triplett +18 more
TL;DR: Detailed differences in metabolic potential indicate that autoimmune subjects have a functionally aberrant microbiome, and data suggest that a consortium of lactate- and butyrate-producing bacteria in a healthy gut induce a sufficient amount of mucin synthesis to maintain gut integrity.