J
Jennifer I. Drake
Researcher at Virginia Commonwealth University
Publications - 17
Citations - 2213
Jennifer I. Drake is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Pulmonary hypertension & Tumor microenvironment. The author has an hindex of 11, co-authored 14 publications receiving 1750 citations.
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Journal ArticleDOI
Function of Mitochondrial Stat3 in Cellular Respiration
Joanna Wegrzyn,Ramesh Potla,Yong Joon Chwae,Naresh Babu V. Sepuri,Qifang Zhang,Thomas Koeck,Marta Derecka,Marta Derecka,Karol Szczepanek,Karol Szczepanek,Magdalena Szelag,Magdalena Szelag,Agnieszka Gornicka,Agnieszka Gornicka,Akira Moh,Shadi Moghaddas,Qun Chen,Santha Bobbili,Joanna Cichy,Jozef Dulak,Darren P. Baker,Alan Wolfman,Dennis J. Stuehr,Dennis J. Stuehr,Medhat O. Hassan,Xin-Yuan Fu,Narayan G. Avadhani,Jennifer I. Drake,Paul Fawcett,Edward J. Lesnefsky,Edward J. Lesnefsky,Andrew C. Larner +31 more
TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
Journal ArticleDOI
The vaginal microbiome and preterm birth
Jennifer M. Fettweis,Myrna G. Serrano,J. Paul Brooks,David J. Edwards,Philippe H. Girerd,Hardik I. Parikh,Bernice Huang,Tom Arodz,Laahirie Edupuganti,Abigail L. Glascock,Jie Xu,Nicole R. Jimenez,Stephany C. Vivadelli,Stephen S. Fong,Nihar U. Sheth,Sophonie Jean,Vladimir Lee,Yahya Bokhari,Ana M. Lara,Shreni D. Mistry,Robert A. Duckworth,Steven P. Bradley,Vishal N. Koparde,X. Valentine Orenda,Sarah Milton,Sarah K. Rozycki,Andrey V. Matveyev,Michelle L. Wright,Michelle L. Wright,Snehalata Huzurbazar,Eugenie M. Jackson,Ekaterina Smirnova,Ekaterina Smirnova,Jonas Korlach,Yu-Chih Tsai,Molly R. Dickinson,Jamie L. Brooks,Jennifer I. Drake,Donald O. Chaffin,Amber L. Sexton,Michael G. Gravett,Craig E. Rubens,N. Romesh Wijesooriya,Karen D. Hendricks-Muñoz,Kimberly K. Jefferson,Jerome F. Strauss,Gregory A. Buck +46 more
TL;DR: A community resource that includes ‘omics’ data from approximately 12,000 samples as part of the integrative Human Microbiome Project is reported, identifying harbingers of preterm birth in this cohort of women predominantly of African ancestry.
Journal ArticleDOI
Molecular Signature of a Right Heart Failure Program in Chronic Severe Pulmonary Hypertension
Jennifer I. Drake,Herman J Bogaard,Shiro Mizuno,Berrick Clifton,Bin Xie,Yuan Gao,Catherine I. Dumur,Paul Fawcett,Norbert F. Voelkel,Ramesh Natarajan +9 more
TL;DR: It is concluded that normal right and left ventricles demonstrate clearly discernable differences in the expression of mRNA and microRNA, and that RVH and RVF are characterized by distinct patterns of gene expression that relate to cell growth, angiogenesis, and energy metabolism.
Journal ArticleDOI
Racioethnic diversity in the dynamics of the vaginal microbiome during pregnancy.
Myrna G. Serrano,Hardik I. Parikh,J. Paul Brooks,David J. Edwards,Tom Arodz,Laahirie Edupuganti,Bernice Huang,Philippe H. Girerd,Yahya Bokhari,Steven P. Bradley,Jamie L. Brooks,Molly R. Dickinson,Jennifer I. Drake,Robert A. Duckworth,Stephen S. Fong,Abigail L. Glascock,Sophonie Jean,Nicole R. Jimenez,Joseph Khoury,Vishal N. Koparde,Ana M. Lara,Vladimir Lee,Andrey V. Matveyev,Sarah Milton,Shreni D. Mistry,Sarah K. Rozycki,Nihar U. Sheth,Ekaterina Smirnova,Stephany C. Vivadelli,N. Romesh Wijesooriya,Jie Xu,Ping Xu,Donald O. Chaffin,Amber L. Sexton,Michael G. Gravett,Michael G. Gravett,Craig E. Rubens,Karen D. Hendricks-Muñoz,Kimberly K. Jefferson,Jerome F. Strauss,Jennifer M. Fettweis,Gregory A. Buck +41 more
TL;DR: In women who experienced normal term births, the vaginal microbiome shifted during pregnancy toward Lactobacillus-dominated profiles at the expense of taxa often associated with vaginal dysbiosis, and were significant only in women of African or Hispanic ancestry.
Journal ArticleDOI
Metabolic Gene Remodeling and Mitochondrial Dysfunction in Failing Right Ventricular Hypertrophy Secondary to Pulmonary Arterial Hypertension
Jose Gomez-Arroyo,Shiro Mizuno,Karol Szczepanek,Benjamin W. Van Tassell,Ramesh Natarajan,Cristobal G. dos Remedios,Jennifer I. Drake,Laszlo Farkas,Donatas Kraskauskas,Dayanjan S. Wijesinghe,Charles E. Chalfant,John W. Bigbee,Antonio Abbate,Edward J. Lesnefsky,Harm Jan Bogaard,Norbert F. Voelkel +15 more
TL;DR: In this article, metabolic gene expression changes and mitochondrial dysfunction in functional and dysfunctional right ventricular (RV) hypertrophy were investigated in two different rat models of RVD, i.e., SU5416/hypoxia and SVH-RVD, and the model of SVH exhibited a significantly decreased gene expression of peroxisome proliferator-activated receptor-γ coactivator-1α and estrogen-related receptor-α.