Q
Qun Chen
Researcher at Virginia Commonwealth University
Publications - 116
Citations - 7518
Qun Chen is an academic researcher from Virginia Commonwealth University. The author has contributed to research in topics: Mitochondrion & Ischemia. The author has an hindex of 36, co-authored 116 publications receiving 6560 citations. Previous affiliations of Qun Chen include Xuzhou Medical College & Case Western Reserve University.
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Journal ArticleDOI
Production of Reactive Oxygen Species by Mitochondria: CENTRAL ROLE OF COMPLEX III *
Qun Chen,Qun Chen,Edwin J. Vazquez,Shadi Moghaddas,Charles L. Hoppel,Charles L. Hoppel,Edward J. Lesnefsky +6 more
TL;DR: In this paper, the authors measured reactive oxygen species (ROS) in the mitochondria of Sprague-Dawley rat heart and corresponding submitochondrial particles using the amplex red assay.
Journal ArticleDOI
Function of Mitochondrial Stat3 in Cellular Respiration
Joanna Wegrzyn,Ramesh Potla,Yong Joon Chwae,Naresh Babu V. Sepuri,Qifang Zhang,Thomas Koeck,Marta Derecka,Marta Derecka,Karol Szczepanek,Karol Szczepanek,Magdalena Szelag,Magdalena Szelag,Agnieszka Gornicka,Agnieszka Gornicka,Akira Moh,Shadi Moghaddas,Qun Chen,Santha Bobbili,Joanna Cichy,Jozef Dulak,Darren P. Baker,Alan Wolfman,Dennis J. Stuehr,Dennis J. Stuehr,Medhat O. Hassan,Xin-Yuan Fu,Narayan G. Avadhani,Jennifer I. Drake,Paul Fawcett,Edward J. Lesnefsky,Edward J. Lesnefsky,Andrew C. Larner +31 more
TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.
Journal ArticleDOI
Sphingosine-1-phosphate produced by sphingosine kinase 2 in mitochondria interacts with prohibitin 2 to regulate complex IV assembly and respiration
Graham M. Strub,M. Paillard,Jie Liang,Ludovic Gomez,Jeremy C. Allegood,Nitai C. Hait,Michael Maceyka,Megan M. Price,Qun Chen,David Simpson,Tomasz Kordula,Sheldon Milstien,Edward J. Lesnefsky,Sarah Spiegel +13 more
TL;DR: It is demonstrated that S1P, produced in the mitochondria mainly by sphin‐gosine kinase 2 (SphK2), binds with high affinity and specificity to prohibitin 2 (PHB2), a highly conserved protein that regulates mitochondrial assembly and function.
Journal ArticleDOI
Ischemic defects in the electron transport chain increase the production of reactive oxygen species from isolated rat heart mitochondria
TL;DR: Findings support that mitochondrial damage occurs during ischemia and contributes to myocardial injury during reperfusion and sets the stage for an increase in ROS production during reperFusion as a mechanism of cardiac injury.
Journal ArticleDOI
Modulation of electron transport protects cardiac mitochondria and decreases myocardial injury during ischemia and reperfusion
Qun Chen,Amadou K.S. Camara,David F. Stowe,David F. Stowe,David F. Stowe,Charles L. Hoppel,Edward J. Lesnefsky,Edward J. Lesnefsky,Edward J. Lesnefsky +8 more
TL;DR: This review addresses the emerging concept that modulation of mitochondrial respiration during and immediately following an episode of ischemia can attenuate the extent of myocardial injury by blocking electron transport and uncoupling respiration.