Ramesh Potla

TL;DR: Data indicate that Stat3 is required for optimal function of the ETC, which may allow it to orchestrate responses to cellular homeostasis.

TL;DR: Regulated relocalization of intestinal Cp may represent a fail-safe mechanism in which Cp shares with Heph responsibility for iron absorption under stress, suggesting a critical function of Cp in basolateral iron transport.

TL;DR: To the authors' surprise, treatment of cells with the HDAC inhibitor, trichostatin A (TSA), inhibits selected interferon β (IFNβ)-stimulated immediate early genes that are activated by the transcription factors Stat1 and Stat2, suggesting that IRF9 functions to recruit RNA polymerase II to the promoter of interferons-stimulated genes.

TL;DR: It is reported that Tyk2-null pro-B cells are markedly deficient in basal oxygen consumption and exhibit a significant decrease in steady-state cellular ATP levels compared to wild-type cells, and expression of a constitutively active Stat3 can restore the mitochondrial respiration in Tyk1-null cells treated with IFN-β.

TL;DR: An important role is demonstrated of Tyk2-mediated tyrosine phosphorylation of Stat3 in the ability of IFNβ to stimulate apoptosis of primary pro-B cells in primary murine interleukin-7-dependent pro- B cells.