J
Jennifer S. Montimurro
Researcher at New York State Department of Health
Publications - 16
Citations - 1981
Jennifer S. Montimurro is an academic researcher from New York State Department of Health. The author has contributed to research in topics: Odds ratio & Single-nucleotide polymorphism. The author has an hindex of 15, co-authored 16 publications receiving 1809 citations. Previous affiliations of Jennifer S. Montimurro include Wadsworth Center.
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Journal ArticleDOI
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease
Taye H. Hamza,Cyrus P. Zabetian,Cyrus P. Zabetian,Albert Tenesa,Alain Laederach,Jennifer S. Montimurro,Dora Yearout,Dora Yearout,Dora Yearout,Denise M. Kay,Kimberly F. Doheny,Justin Paschall,Elizabeth W. Pugh,Victoria I. Kusel,Randall V. Collura,John W. Roberts,Alida Griffith,Ali Samii,Ali Samii,William K. Scott,John G. Nutt,Stewart A. Factor,Haydeh Payami,Haydeh Payami +23 more
TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.
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Genome-Wide Gene-Environment Study Identifies Glutamate Receptor Gene GRIN2A as a Parkinson's Disease Modifier Gene via Interaction with Coffee
Taye H. Hamza,Honglei Chen,Erin M. Hill-Burns,Shannon L. Rhodes,Jennifer S. Montimurro,Denise M. Kay,Albert Tenesa,Victoria I. Kusel,Patricia Sheehan,Muthukrishnan Eaaswarkhanth,Dora Yearout,Dora Yearout,Ali Samii,John W. Roberts,Pinky Agarwal,Yvette Bordelon,Yikyung Park,Liyong Wang,Jianjun Gao,Jeffery M. Vance,Kenneth S. Kendler,Silviu Alin Bacanu,William K. Scott,Beate Ritz,John G. Nutt,Stewart A. Factor,Cyrus P. Zabetian,Haydeh Payami +27 more
TL;DR: This study is proof of concept that inclusion of environmental factors can help identify genes that are missed in GWAS and may be a useful pharmacogenetic marker for subdividing individuals in clinical trials to determine which medications might work best for which patients.
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Association analysis of MAPT H1 haplotype and subhaplotypes in Parkinson's disease
Cyrus P. Zabetian,Carolyn M. Hutter,Stewart A. Factor,John G. Nutt,Donald S. Higgins,Alida Griffith,John W. Roberts,Berta C. Leis,Denise M. Kay,Dora Yearout,Dora Yearout,Jennifer S. Montimurro,Karen L. Edwards,Ali Samii,Ali Samii,Haydeh Payami +15 more
TL;DR: An inversion polymorphism of approximately 900kb on chromosome 17q21, which includes the microtubule‐associated protein tau (MAPT) gene defines two haplotype clades, H1 and H2, which are observed to have a marginally significant excess among patients with Parkinson's disease.
Journal ArticleDOI
Combined effects of smoking, coffee, and NSAIDs on Parkinson's disease risk.
Karen M. Powers,Denise M. Kay,Stewart A. Factor,Stewart A. Factor,Cyrus P. Zabetian,Donald S. Higgins,Ali Samii,John G. Nutt,Alida Griffith,Berta C. Leis,John W. Roberts,Erica Martinez,Jennifer S. Montimurro,Harvey Checkoway,Haydeh Payami +14 more
TL;DR: Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose–response relations, and persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk.
Journal ArticleDOI
Heterozygous parkin point mutations are as common in control subjects as in Parkinson's patients.
Denise M. Kay,Dawn Moran,Dawn Moran,Lina M. Moses,Parvoneh Poorkaj,Parvoneh Poorkaj,Cyrus P. Zabetian,Cyrus P. Zabetian,John G. Nutt,Stewart A. Factor,Stewart A. Factor,Chang En Yu,Chang En Yu,Jennifer S. Montimurro,Robert G. Keefe,Gerard D. Schellenberg,Gerard D. Schellenberg,Haydeh Payami +17 more
TL;DR: A comprehensive sequence analysis of parkin in control subjects is presented and it is shown that single “mutation” in a patient is related to disease or is coincidental, because the mutation frequency in control Subjects is unknown.