Denise M. Kay

TL;DR: Mutations in LRRK2 are a clinically relevant cause of PD that merit testing in patients with hereditary PD and in subgroups of patients with PD, but this knowledge should be applied with caution in the diagnosis and counselling of patients.

TL;DR: The genome-wide association study of 2,000 individuals with Parkinson's disease and unaffected controls confirmed associations with SNCA and MAPT and detected a new association with the HLA region, which was uniform across all genetic and environmental risk strata and was strong in sporadic and late-onset disease.

TL;DR: An inversion polymorphism of approximately 900kb on chromosome 17q21, which includes the microtubule‐associated protein tau (MAPT) gene defines two haplotype clades, H1 and H2, which are observed to have a marginally significant excess among patients with Parkinson's disease.

TL;DR: Smoking and coffee exhibited significant inverse risk trends with increasing cumulative exposures, suggesting dose–response relations, and persons who were at the highest exposure strata for smoking and coffee and used NSAIDs had an estimated 87% reduction in risk.

TL;DR: A comprehensive sequence analysis of parkin in control subjects is presented and it is shown that single “mutation” in a patient is related to disease or is coincidental, because the mutation frequency in control Subjects is unknown.