J
Jeremy J. Wolff
Researcher at Bruker
Publications - 41
Citations - 1216
Jeremy J. Wolff is an academic researcher from Bruker. The author has contributed to research in topics: Mass spectrometry & Fourier transform ion cyclotron resonance. The author has an hindex of 17, co-authored 39 publications receiving 1001 citations. Previous affiliations of Jeremy J. Wolff include University of Wisconsin-Madison.
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Journal ArticleDOI
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.
Daniel P. Donnelly,Catherine M. Rawlins,Caroline J. DeHart,Luca Fornelli,Luis F. Schachner,Ziqing Lin,Jennifer L. Lippens,Krishna Aluri,Krishna Aluri,Richa Sarin,Richa Sarin,Bifan Chen,Carter Lantz,Wonhyeuk Jung,Kendall Johnson,Antonius Koller,Jeremy J. Wolff,Iain D. G. Campuzano,Jared R. Auclair,Alexander R. Ivanov,Julian P. Whitelegge,Ljiljana Paša-Tolić,Julia Chamot-Rooke,Paul O. Danis,Lloyd M. Smith,Yury O. Tsybin,Joseph A. Loo,Ying Ge,Neil L. Kelleher,Jeffrey N. Agar +29 more
TL;DR: The Consortium for Top-Down Proteomics presents a decision-tree-based guide to sample preparation and analysis protocols for researchers performing top-down mass-spectrometry-based analysis of intact proteins.
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Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743
Christopher M. Rath,Benjamin Janto,Josh Earl,Azad Ahmed,Fen Z. Hu,Fen Z. Hu,Luisa Hiller,Meg Dahlgren,Rachael Kreft,Fengan Yu,Jeremy J. Wolff,Hye Kyong Kweon,Mike A Christiansen,Kristina Håkansson,Robert M. Williams,Garth D. Ehrlich,Garth D. Ehrlich,David H. Sherman +17 more
TL;DR: This work focuses on the ET-743 (Yondelis) biosynthetic pathway, which is an approved anticancer agent obtained in low abundance from the tunicate Ecteinascidia turbinata and generated in suitable quantities for clinical use by a lengthy semisynthetic process.
Journal ArticleDOI
Native top-down electrospray ionization-mass spectrometry of 158 kDa protein complex by high-resolution Fourier transform ion cyclotron resonance mass spectrometry.
TL;DR: In this paper, the authors reported isotopic resolution of a tetrameric aldolase with an average absolute deviation of 0.36 ppm and an average resolving power of ∼520,000 at m/z 6033 for the 26+ charge state in magnitude mode.
Journal ArticleDOI
The first pilot project of the consortium for top-down proteomics: A status report
Xibei Dang,Jenna Scotcher,Jenna Scotcher,Si Wu,Rosalie K. Chu,Nikola Tolić,Ioanna Ntai,Paul M. Thomas,Ryan T. Fellers,Bryan P. Early,Yupeng Zheng,Kenneth R. Durbin,Richard D. LeDuc,Jeremy J. Wolff,Christopher J. Thompson,Jingxi Pan,Jun Han,Jared B. Shaw,Joseph P. Salisbury,Michael L. Easterling,Christoph H. Borchers,Jennifer S. Brodbelt,Jeffery N. Agar,Ljiljana Paša-Tolić,Neil L. Kelleher,Nicolas L. Young +25 more
TL;DR: Initial results from seven participating laboratories reported the probability‐based identification of human histone H4 (UniProt accession P62805) with expectation values ranging from 10−13 to 10−105; Regarding characterization, a total of 74 proteoforms were reported, with 21 done so unambiguously; one new PTM, K79ac, was identified.