A
Alexander R. Ivanov
Researcher at Northeastern University
Publications - 113
Citations - 5744
Alexander R. Ivanov is an academic researcher from Northeastern University. The author has contributed to research in topics: Mass spectrometry & Medicine. The author has an hindex of 33, co-authored 94 publications receiving 4464 citations. Previous affiliations of Alexander R. Ivanov include Cardiovascular Institute of the South & Massachusetts Eye and Ear Infirmary.
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Journal ArticleDOI
Aberrant lipid metabolism disrupts calcium homeostasis causing liver endoplasmic reticulum stress in obesity
Suneng Fu,Ling Yang,Ping Li,Oliver Hofmann,Lee H. Dicker,Winston Hide,Xihong Lin,Steven M. Watkins,Alexander R. Ivanov,Goekhan S. Hotamisligil,Goekhan S. Hotamisligil +10 more
TL;DR: Correcting the obesity-induced alteration of ER phospholipid composition or hepatic Serca overexpression in vivo both reduced chronic ER stress and improved glucose homeostasis is established.
Journal ArticleDOI
How many human proteoforms are there
Ruedi Aebersold,Jeffrey N. Agar,I. Jonathan Amster,Mark S. Baker,Carolyn R. Bertozzi,Emily S. Boja,Catherine E. Costello,Benjamin F. Cravatt,Catherine Fenselau,Benjamin A. Garcia,Ying Ge,Jeremy Gunawardena,Ronald C. Hendrickson,Paul J. Hergenrother,Christian G. Huber,Alexander R. Ivanov,Ole N. Jensen,Michael C. Jewett,Neil L. Kelleher,Laura L. Kiessling,Nevan J. Krogan,Martin R. Larsen,Joseph A. Loo,Rachel R. Ogorzalek Loo,Emma Lundberg,Emma Lundberg,Michael J. MacCoss,Parag Mallick,Vamsi K. Mootha,Milan Mrksich,Tom W. Muir,Steven M. Patrie,James J. Pesavento,Sharon J. Pitteri,Henry Rodriguez,Alan Saghatelian,Wendy Sandoval,Hartmut Schlüter,Salvatore Sechi,Sarah A. Slavoff,Lloyd M. Smith,Michael Snyder,Paul M. Thomas,Mathias Uhlén,Jennifer E. Van Eyk,Marc Vidal,David R. Walt,Forest M. White,Evan R. Williams,Therese Wohlschlager,Vicki H. Wysocki,Nathan A. Yates,Nicolas L. Young,Bing Zhang +53 more
TL;DR: This work frames central issues regarding determination of protein-level variation and PTMs, including some paradoxes present in the field today, and uses this framework to assess existing data and ask the question, "How many distinct primary structures of proteins (proteoforms) are created from the 20,300 human genes?"
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Malaria-Infected Erythrocyte-Derived Microvesicles Mediate Cellular Communication within the Parasite Population and with the Host Immune System
Pierre-Yves Mantel,Anh N. Hoang,Ilana Goldowitz,Daria M. Potashnikova,Daria M. Potashnikova,Bashar Hamza,Ivan A. Vorobjev,Ivan A. Vorobjev,Ionita Ghiran,Mehmet Toner,Daniel Irimia,Alexander R. Ivanov,Natasha S. Barteneva,Natasha S. Barteneva,Matthias Marti +14 more
TL;DR: RMVs demonstrate potent immunomodulatory properties on human primary macrophages and neutrophils and stimulate production of transmission stage parasites in a dose-dependent manner, which mediate cellular communication within the parasite population and with the host innate immune system.
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Zcchc11-dependent uridylation of microRNA directs cytokine expression
Matthew R. Jones,Lee J. Quinton,Matthew T. Blahna,Joel R. Neilson,Suneng Fu,Alexander R. Ivanov,Dieter A. Wolf,Dieter A. Wolf,Joseph P. Mizgerd +8 more
TL;DR: Zcchc11 fine tunes IL-6 production by uridylating miR-26a, which is proposed is an enzymatic modification of the terminal nucleotide sequence of mature miRNA as a means to regulate gene expression.
Journal ArticleDOI
Best practices and benchmarks for intact protein analysis for top-down mass spectrometry.
Daniel P. Donnelly,Catherine M. Rawlins,Caroline J. DeHart,Luca Fornelli,Luis F. Schachner,Ziqing Lin,Jennifer L. Lippens,Krishna Aluri,Krishna Aluri,Richa Sarin,Richa Sarin,Bifan Chen,Carter Lantz,Wonhyeuk Jung,Kendall Johnson,Antonius Koller,Jeremy J. Wolff,Iain D. G. Campuzano,Jared R. Auclair,Alexander R. Ivanov,Julian P. Whitelegge,Ljiljana Paša-Tolić,Julia Chamot-Rooke,Paul O. Danis,Lloyd M. Smith,Yury O. Tsybin,Joseph A. Loo,Ying Ge,Neil L. Kelleher,Jeffrey N. Agar +29 more
TL;DR: The Consortium for Top-Down Proteomics presents a decision-tree-based guide to sample preparation and analysis protocols for researchers performing top-down mass-spectrometry-based analysis of intact proteins.