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Christopher M. Rath
Researcher at Novartis
Publications - 33
Citations - 1829
Christopher M. Rath is an academic researcher from Novartis. The author has contributed to research in topics: Bacterial outer membrane & Lipid A. The author has an hindex of 20, co-authored 32 publications receiving 1558 citations. Previous affiliations of Christopher M. Rath include University of California, San Diego & University of Montana.
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Journal ArticleDOI
Molecular Networking as a Dereplication Strategy
Jane Y. Yang,Laura M. Sanchez,Christopher M. Rath,Xueting Liu,Paul D. Boudreau,Nicole Bruns,Evgenia Glukhov,Anne Wodtke,Rafael de Felício,Rafael de Felício,Amanda M. Fenner,Weng Ruh Wong,Roger G. Linington,Lixin Zhang,Hosana Maria Debonsi,William H. Gerwick,Pieter C. Dorrestein +16 more
TL;DR: It is demonstrated here that molecular networking, an approach that organizes MS/MS data based on chemical similarity, is a powerful complement to traditional dereplication strategies, and is applied to a diverse array of marine and terrestrial microbial samples.
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Molecular cartography of the human skin surface in 3D
Amina Bouslimani,Carla Porto,Christopher M. Rath,Mingxun Wang,Yurong Guo,Antonio Gonzalez,Donna Berg-Lyon,Gail Ackermann,Gitte J. M. Christensen,Teruaki Nakatsuji,Ling-juan Zhang,Andrew W. Borkowski,Michael J. Meehan,Kathleen Dorrestein,Richard L. Gallo,Nuno Bandeira,Rob Knight,Theodore Alexandrov,Pieter C. Dorrestein +18 more
TL;DR: 3D mapping of mass spectrometry data and microbial 16S rRNA amplicon sequences reveals that the molecular composition of skin has diverse distributions and that the composition is defined not only by skin cells and microbes but also by the authors' daily routines, including the application of hygiene products.
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Meta-omic characterization of the marine invertebrate microbial consortium that produces the chemotherapeutic natural product ET-743
Christopher M. Rath,Benjamin Janto,Josh Earl,Azad Ahmed,Fen Z. Hu,Fen Z. Hu,Luisa Hiller,Meg Dahlgren,Rachael Kreft,Fengan Yu,Jeremy J. Wolff,Hye Kyong Kweon,Mike A Christiansen,Kristina Håkansson,Robert M. Williams,Garth D. Ehrlich,Garth D. Ehrlich,David H. Sherman +17 more
TL;DR: This work focuses on the ET-743 (Yondelis) biosynthetic pathway, which is an approved anticancer agent obtained in low abundance from the tunicate Ecteinascidia turbinata and generated in suitable quantities for clinical use by a lengthy semisynthetic process.
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In Vivo and In Vitro Trans-Acylation by BryP, the Putative Bryostatin Pathway Acyltransferase Derived from an Uncultured Marine Symbiont
Nicole B. Lopanik,Jennifer A. Shields,Tonia J. Buchholz,Christopher M. Rath,Joanne Hothersall,Margo G. Haygood,Kristina Håkansson,Christopher M. Thomas,David H. Sherman +8 more
TL;DR: Biochemical characterization demonstrated that BryP catalyzes selective malonyl-CoA acylation of native and heterologous acyl carrier proteins and complete PKS modules in vitro, and provides the first biochemical evidence of the functionality of the bry cluster.
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Structures and cytotoxic properties of trichoverroids and their macrolide analogues produced by saltwater culture of Myrothecium verrucaria.
Taro Amagata,Christopher M. Rath,Jérome F. Rigot,Nick Tarlov,Karen Tenney,Frederick A. Valeriote,Phillip Crews +6 more
TL;DR: Saltwater culture of Myrothecium verrucaria was a source of three new trichothecenes, 3-hydroxyroridin E, 13'-acetyltrichoverrin B, and miophytocen C and nine known related compounds, which showed significant cytotoxicity against murine and human tumor cell lines.