Jeroen Kortekaas

TL;DR: Mechanisms that govern neuropathogenesis and immunopathogenesis of viral infections are highlighted, using examples of well-studied virus infections that are associated with these alterations in different populations throughout the world.

TL;DR: It is demonstrated that a single intramuscular vaccination with RRPs protects mice from a lethal dose of RVFV and show that RRPs can be used for rapid virus neutralization tests that do not require biocontainment facilities.

TL;DR: It is reported that the glycosaminoglycan heparan sulfate, abundantly present on the surface of most animal cells, is required for efficient entry of Rift Valley fever virus.

TL;DR: Evaluation of two vaccine candidates based on the viral Gn and Gc envelope glycoproteins produced in a Drosophila insect cell expression system shows absence of the nucleocapsid protein in either vaccine candidate facilitates the differentiation between infected and vaccinated animals using a commercial recombinant nucleocAPSid protein-based indirect ELISA.

TL;DR: The production of Gn and Gc is reported by a recombinant vaccine strain of the avian paramyxovirus Newcastle disease virus (NDV) and it is demonstrated that intramuscular vaccination with this experimental NDV-based vector vaccine provides complete protection in mice.