J
Jia-Ren Lin
Researcher at Harvard University
Publications - 55
Citations - 8431
Jia-Ren Lin is an academic researcher from Harvard University. The author has contributed to research in topics: Tumor microenvironment & Cell cycle. The author has an hindex of 23, co-authored 51 publications receiving 5029 citations. Previous affiliations of Jia-Ren Lin include National Taiwan University & Stanford University.
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Dosage of Dyrk1a Shifts Cells within a p21-Cyclin D1 Signaling Map to Control the Decision to Enter the Cell Cycle
TL;DR: It is shown that increased dosage of chromosome 21-localized Dyrk1a steeply increases G1 cell cycle duration through direct phosphorylation and degradation of cyclin D1 (CycD1) and Down syndrome-derived fibroblasts showed analogous cell cycle changes that were reversed by DyrK1a inhibition.
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Targeting immunosuppressive macrophages overcomes PARP inhibitor resistance in BRCA1-associated triple-negative breast cancer.
Anita K. Mehta,Emily M. Cheney,Christina A. Hartl,Constantia Pantelidou,Madisson Oliwa,Jessica A. Castrillon,Jia-Ren Lin,Katie E. Hurst,Mateus de Oliveira Taveira,Nathan T. Johnson,William M. Oldham,Marian Kalocsay,Matthew J. Berberich,Sarah A. Boswell,Aditi Kothari,Shawn F. Johnson,Deborah A. Dillon,Mikel Lipschitz,Mikel Lipschitz,Scott J. Rodig,Scott J. Rodig,Sandro Santagata,Sandro Santagata,Judy Garber,Nadine Tung,José Yélamos,Jessica E. Thaxton,Elizabeth A. Mittendorf,Elizabeth A. Mittendorf,Peter K. Sorger,Geoffrey I. Shapiro,Geoffrey I. Shapiro,Jennifer L. Guerriero +32 more
TL;DR: It is demonstrated that macrophages are the predominant infiltrating immune cell type in BRCA-associated TNBC and that combined PARP inhibition and macrophage targeting therapy induces a durable reprogramming of the tumor microenvironment, thus constituting a promising therapeutic strategy for TNBC.
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Uncoordinated regulation of stress fibers and focal adhesions by DAP kinase.
TL;DR: A novel and unique function of DAP kinase is identified in the uncoupling of stress fibers and focal adhesions, which would lead to a perturbation of the balance between contractile and adhesion forces and subsequent cell detachment, which might contribute to its pro-apoptotic activity.
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Qualifying Antibodies for Image-Based Immune Profiling and Multiplexed Tissue Imaging
Ziming Du,Ziming Du,Jia-Ren Lin,Rumana Rashid,Rumana Rashid,Zoltan Maliga,Shu Wang,Jon C. Aster,Jon C. Aster,Benjamin Izar,Peter K. Sorger,Sandro Santagata +11 more
TL;DR: This protocol provides step-by-step procedures for confirming the selectivity and specificity of antibodies used in fluorescence-based tissue imaging and for the construction and validation of antibody panels for FFPE tissue sections using cyclic immunofluorescence (t-CyCIF) or other multiplexed imaging methods.
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MCMICRO: a scalable, modular image-processing pipeline for multiplexed tissue imaging
Denis Schapiro,Artem Sokolov,Clarence Yapp,Yu-An Chen,Jeremy L. Muhlich,Joshua Hess,Allison L. Creason,Ajit J. Nirmal,Gregory J. Baker,Maulik K. Nariya,Jia-Ren Lin,Zoltan Maliga,Connor A. Jacobson,Matthew W. Hodgman,Matthew W. Hodgman,Juha Ruokonen,Samouil L. Farhi,Domenic Abbondanza,Eliot T. McKinley,Eliot T. McKinley,Daniel Persson,Courtney Betts,Shamilene Sivagnanam,Aviv Regev,Aviv Regev,Aviv Regev,Jeremy Goecks,Robert J. Coffey,Lisa M. Coussens,Sandro Santagata,Sandro Santagata,Peter K. Sorger +31 more
TL;DR: MCMICRO as discussed by the authors is a modular and open-source computational pipeline for transforming highly multiplexed whole-slide images of tissues into single-cell data, which can be used with CODEX, mxIF, CyCIF, mIHC and H&E staining data.