Jia-Ren Lin

TL;DR: A text mining tool that analyzes the PubMed literature database and integrates the available genomic information to provide a detailed mapping of the genes and their interrelationships within a particular network such as osteoporosis shows that existing genomic data within the PubMed database can effectively be used to predict potentially novel target genes for osteop orosis research that have not previously been reported in the literature.

TL;DR: Deubiquitination of Rad18 drives its localization to sites of DNA damage and formation of the Rad18–SHPRH complexes necessary for error-free lesion bypass.

TL;DR: Both the response and resistance to BET inhibitors in mice is mediated by bHLH/homeobox transcription factors, which provides insights about the mechanisms underlying BETi effects and the appearance of resistance and support the therapeutic use of combined cell-cycle inhibitors with BETi in MYC-amplified medulloblastoma.

TL;DR: A metabolic vulnerability of cells with Sirtuin 3 loss is uncovered by using an unbiased small-molecule screen and it is found that SIRT3 KO cells upregulated the diversion of glutamine into de novo nucleotide synthesis through hyperactive mTORC1 signaling.

TL;DR: It is demonstrated that non-specific interactions lead to very slow incorporation kinetics of DNA binding drugs, which leads to virtually irreversible binding of the drug to specific DNA targets in cells.