Jiahua Wang

TL;DR: It is demonstrated that Zc3h13 plays a critical role in anchoring WTAP, Virilizer, and Hakai in the nucleus to facilitate m6A methylation and to regulate mESC self-renewal.

TL;DR: It is demonstrated that METTL3-catalysed m6A modification of RNA is important for the integrity of IAP heterochromatin in mouse embryonic stem cells, revealing a mechanism of heterochromeatin regulation in mammals.

TL;DR: Wang et al. as discussed by the authors demonstrated that the METTL3/METTL14/WTAP m6A methyltransferase complex (MTC) is localized to many promoters and enhancers and deposits the m6a modification on nascent transcripts, including pre-mRNAs, promoter upstream transcripts (PROMPTs), and enhancer RNAs.

TL;DR: This work constructed a portion of the YTHDF2 protein containing a low complexity (LC) domain, and found these droplets fuse with each other to form bigger droplets, which suggests a liquid like phase separation feature of Y THDF2 230−383.

TL;DR: It is demonstrated that efSaCas9 possesses higher cleavage activity and fidelity than SaCas9-HF at the most endogenous sites in human cells, which provides insights for the rational selection of suitable Sa Cas9 for human genome editing.