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Wenqi Xu
Researcher at Fudan University
Publications - 17
Citations - 1634
Wenqi Xu is an academic researcher from Fudan University. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 10, co-authored 14 publications receiving 1251 citations. Previous affiliations of Wenqi Xu include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Loss of 5-Hydroxymethylcytosine Is an Epigenetic Hallmark of Melanoma
Christine G. Lian,Yufei Xu,Craig J. Ceol,Craig J. Ceol,Feizhen Wu,Allison R. Larson,Karen Dresser,Wenqi Xu,Li Tan,Yeguang Hu,Qian Zhan,Chung-Wei Lee,Di Hu,Bill Q. Lian,Bill Q. Lian,Sonja Kleffel,Yijun Yang,James Neiswender,Abraham J. Khorasani,Rui Fang,Cecilia Lezcano,Lyn M. Duncan,Richard A. Scolyer,John F. Thompson,Hojabr Kakavand,Yariv Houvras,Yariv Houvras,Leonard I. Zon,Martin C. Mihm,Ursula B. Kaiser,Tobias Schatton,Bruce A. Woda,George F. Murphy,Yujiang Geno Shi,Yujiang Geno Shi +34 more
TL;DR: This study reveals a critical function of 5-hmC in melanoma development and directly links the IDH and TET activity-dependent epigenetic pathway to 5-mC-mediated suppression of melanoma progression, suggesting a new strategy for epigenetic cancer therapy.
Journal ArticleDOI
BS69/ZMYND11 Reads and Connects Histone H3.3 Lysine 36 Trimethylation-Decorated Chromatin to Regulated Pre-mRNA Processing
Rui Guo,Lijuan Zheng,Juw Won Park,Ruitu Lv,Hao Chen,Fangfang Jiao,Wenqi Xu,Shi-Rong Mu,Hong Wen,Jinsong Qiu,Zhentian Wang,Pengyuan Yang,Feizhen Wu,Jingyi Hui,Xiang-Dong Fu,Xiaobing Shi,Xiaobing Shi,Yujiang Geno Shi,Yi Xing,Fei Lan,Yang Shi,Yang Shi,Yang Shi +22 more
TL;DR: This study identifies an H.3.3K36me3-specific reader and a regulator of IR and reveals that BS69 connects histone H3.
Journal ArticleDOI
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation
Shuzhen Chen,Jian Ma,Feizhen Wu,Li Jun Xiong,Honghui Ma,Wenqi Xu,Ruitu Lv,Xiaodong Li,Judit Villén,Steven P. Gygi,Xiaole Shirley Liu,Yang Shi +11 more
TL;DR: The model whereby JMJD3 activates bivalent gene transcription by demethylating H3K27me3 and promoting transcriptional elongation is supported, and new insight is provided into the mechanisms by whichJMJD3 regulates gene expression.
Journal ArticleDOI
METTL3 regulates heterochromatin in mouse embryonic stem cells
Wenqi Xu,Jiahui Li,Chenxi He,Jing Wen,Honghui Ma,Bowen Rong,Jianbo Diao,Liyong Wang,Jiahua Wang,Feizhen Wu,Li Tan,Yujiang Geno Shi,Yang Shi,Hongjie Shen +13 more
TL;DR: It is demonstrated that METTL3-catalysed m6A modification of RNA is important for the integrity of IAP heterochromatin in mouse embryonic stem cells, revealing a mechanism of heterochromeatin regulation in mammals.
Journal ArticleDOI
Suppression of Enhancer Overactivation by a RACK7-Histone Demethylase Complex.
Hongjie Shen,Wenqi Xu,Rui Guo,Bowen Rong,Lei Gu,Zhentian Wang,Chenxi He,Lijuan Zheng,Xin Hu,Zhen Hu,Zhi Ming Shao,Pengyuan Yang,Feizhen Wu,Yujiang Geno Shi,Yujiang Geno Shi,Yang Shi,Yang Shi,Fei Lan +17 more
TL;DR: It is proposed that RACK7/KDM5C functions as an enhancer "brake" to ensure appropriate enhancer activity, which, when compromised, could contribute to tumorigenesis.