Showing papers by "Jiang-Ning Zhou published in 2007"
TL;DR: The study suggests that the MT1-mediated effects of melatonin on the SCN are disturbed during aging and even more so in late stage AD, which may contribute to the clinical circadian disorders and to the efficacy of therapeutic melatonin administration under these conditions.
184 citations
TL;DR: Lithium up-regulates the generation and survival of new-born cells in the hippocampus by the ERK pathway and improves the behavioral disorder in rats after transient global cerebral ischemia.
117 citations
TL;DR: This study confirmed the protective role of lithium in the ischemia-reperfusion injury and suggested that lithium might be a helpful therapeutic approach to the treatment of stroke combining with other neuroprotective agents.
83 citations
TL;DR: The result suggests that the molecular mechanism underlying the treatment of depression with mifepristone is associated with the rapid repair of the synaptic alteration.
79 citations
TL;DR: It is shown for the first time that astrocytes from the rat cortex and glioma C6 cell line synthesize melatonin in vitro, showing the presence of serotonin, the precursor of melatonin and the two key enzymes in the pathway ofmelatonin synthesis, i.e. N‐acetyltransferase and hydroxyndole‐O‐methyltransferase in the cultured rat cortical astroCytes.
Abstract: Melatonin not only plays a major role in the regulation of circadian rhythms, but is also involved in antioxidative defense and immunomodulation. Circulating melatonin levels are derived primarily from the pineal gland while other sources of melatonin have also been reported. Here, we show for the first time that astrocytes from the rat cortex and glioma C6 cell line synthesize melatonin in vitro. In addition, we show the presence of serotonin, the precursor of melatonin and the two key enzymes in the pathway of melatonin synthesis, i.e. N-acetyltransferase and hydroxyndole-O-methyltransferase in the cultured rat cortical astrocytes. Release of melatonin into the culture medium showed no diurnal changes. These point to astrocytes as a local source of melatonin in the rat brain. Its exact physiological function remains a topic for future studies.
66 citations
TL;DR: The results suggest that the contribution of Ser129-phosphorylated α-syn to the Lys63-linked Ub-conjugates and aggregation of itself may be involved in the biogenesis of LBs in Parkinson disease and other related synucleinopathies.
50 citations
46 citations
TL;DR: It is suggested that adult-onset hypothyroidism could induce an age- and task-dependent impairment of memory in female KM mice.
45 citations
TL;DR: In vitro phoshorylation assays indicate that Nurr1 phosphorylation by ERK2 may play a role in regulating the TH expression, and overexpression of a constitutively active form of MEK1, together with Nurr 1 and mouse ERK 2, greatly increases the tyrosine hydroxylase expression in SH-SY5Y cells.
43 citations
TL;DR: It is suggested that increased Syt 1 in the dorsal hippocampus in aged mice might be responsible for the age-related impairment of learning and memory.
39 citations
TL;DR: The results suggested that the age-related anxiety levels of SAMP8 mice are sex- and task-specific, and showed a tendency toward increased anxiety with age as measured by the time spent on the open arms of elevated plus maze.
TL;DR: The results suggest that NgR may be related to the formation of tangles in AD, and high numbers of AT-8 immunopositive cells were found to be double-labeled with NgR in the CA1 subfields of patients with AD.
TL;DR: Data provide evidence that p45 plays an important role in regulating ataxin‐3 degradation by the proteasome, and it is shown that other three ATPases of the 19S proteasomes, MSS1, p48, and p56 have no effect on ataxIn‐3 degrade.
Abstract: Machado-Joseph disease (MJD) is an autosomal dominant neurodegenerative disorder caused by an expansion of the polyglutamine tract near the C-terminus of the MJD-1 gene product, ataxin-3. Ataxin-3 is degraded by the proteasome. However, the precise mechanism of ataxin-3 degradation remains to be elucidated. In this study, we show direct links between ataxin-3 and the proteasome. p45, an ATPase subunit of the 19S proteasome, interacts with ataxin-3 in vitro and stimulates the degradation of ataxin-3 in an in vitro reconstituted degradation assay system. The effect of p45 on ataxin-3 degradation is blocked by MG132, a proteasome inhibitor. In N2a or 293 cells, overexpression of p45 strikingly enhances the clearance of both normal and expanded ataxin-3, but not alpha synuclein or SOD1, implying a functional specificity of p45 in this proteolytic process. The N-terminus of ataxin-3, which serves as a recognition site by p45, is necessary for the proteolytic process of ataxin-3. We also show that other three ATPases of the 19S proteasome, MSS1, p48, and p56 have no effect on ataxin-3 degradation. These data provide evidence that p45 plays an important role in regulating ataxin-3 degradation by the proteasome.
Journal Article•
TL;DR: Salivary serotonin in patients with major depressive disorder showed clear circadian rhythm and the serotonin circadian amplitude (After minus Before) was positively correlated with the decrease of Zung Self-Rating Depression Scale scores at day 42 whereas there was no such correlation at day 28.
Abstract: OBJECTIVES: The present study aimed to explore the circadian rhythm of salivary serotonin in patients with major depressive disorder before and after treatment with fluoxetine and its relationship with clinical therapeutic effect. METHODS: This study investigated salivary serotonin in 13 outpatients with major depressive disorder and age- and sex-matched healthy controls. Depressed patients received six weeks fluoxetine treatment (20 mg/day), saliva was collected before and four weeks after treatment. A total of 8 time-point salivary serotonin was measured across the whole day. Multioscillator cosinor model was used to fit the rhythms. RESULTS: Serotonin concentration in saliva ranged from 0.32 ng/ml to 9.62 ng/ml. Salivary serotonin showed prominent circadian rhythm in 91% depressed patients and 92% healthy subjects. Circadian amplitude tend to be higher after fluoxetine treatment in depressed patients, so as the ultradian cycle amplitude. The Δ serotonin circadian amplitude (After minus Before) was positively correlated with the decrease of Zung Self-Rating Depression Scale(SDS) scores at day 42 whereas there was no such correlation at day 28. There was no significant difference in the parameters of mesor, acrophase, harmonic and area under curve among three groups. CONCLUSIONS: Salivary serotonin in patients with major depressive disorder showed clear circadian rhythm. The relationship between the increase of salivary serotonin amplitude and clinical response deserve further study. 1. 2. 3.
TL;DR: The results suggest that quercetin has possible effects in information processing within a neuronal network by inhibition of I(Gly) and may be useful as a pharmacological probe for identifying the subunit types of GlyRs.
Journal Article•
TL;DR: To the authors' surprise, the melatonin amplitude (Before minus After) was positively correlated with the improvement in Hamilton Depression Rating Scale (HDRS) scores at day 42 whereas there was no such correlation at day 28, and the interesting finding that the difference of salivaryMelatonin amplitude was correlation with the clinical improvement after six weeks fluoxetine treatment deserve further study.
Abstract: Community acquired bacterial (CBM) meningitis in diabetic patients was analyzed for risk factors and outcome in a cohort of 201 cases of meningitis within last 17 years: 15 patients with diabetes mellitus and meningitis were identified and compared for etiology and mortality as well as for neurologic sequellae with all CBM cases.