J
Jiangang Shen
Researcher at University of Hong Kong
Publications - 179
Citations - 8185
Jiangang Shen is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Neuroprotection & Peroxynitrite. The author has an hindex of 45, co-authored 167 publications receiving 5777 citations. Previous affiliations of Jiangang Shen include Guangzhou University & Academia Sinica.
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Journal ArticleDOI
Caveolin‐1 regulates nitric oxide‐mediated matrix metalloproteinases activity and blood–brain barrier permeability in focal cerebral ischemia and reperfusion injury
Yong Gu,Guo-Qing Zheng,Guo-Qing Zheng,Mingjing Xu,Yue Li,Xingmiao Chen,Wenzong Zhu,Yao Tong,Sookja K. Chung,Ke Jian Liu,Jiangang Shen +10 more
TL;DR: In this paper, the role of cavolin-1 (cav-1) in regulating blood-brain barrier (BBB) permeability is investigated in the context of cerebral ischemia-reperfusion injury.
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Normobaric hyperoxia attenuates early blood-brain barrier disruption by inhibiting MMP-9-mediated occludin degradation in focal cerebral ischemia
TL;DR: It is suggested that NBO attenuates early BBB disruption, and inhibition of MMP‐9‐mediated occludin degradation is an important mechanism for this protection.
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A review: The pharmacology of isoliquiritigenin
Fu Peng,Fu Peng,Qiaohui Du,Cheng Peng,Neng Wang,Hailin Tang,Hailin Tang,Xiaoming Xie,Jiangang Shen,Jianping Chen,Jianping Chen +10 more
TL;DR: This review aims at providing a comprehensive summary of the pharmacological activities of ISL from a number of reliable sources including PubMed, ScienceDirect, Springer, and Wiley‐Blackwell.
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Ellagic acid, a phenolic compound, exerts anti-angiogenesis effects via VEGFR-2 signaling pathway in breast cancer
Neng Wang,Zhiyu Wang,Sui-Lin Mo,Tjing Yung Loo,Dongmei Wang,Hai Bin Luo,Depo Yang,Yuling Chen,Jiangang Shen,Jianping Chen +9 more
TL;DR: Ellagic acid significantly inhibited a series of VEGF-induced angiogenesis processes including proliferation, migration, and tube formation of endothelial cells and directly inhibited VEGFR-2 tyrosine kinase activity and its downstream signaling pathways including MAPK and PI3K/Akt in endothelial Cells.
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Dietary Compound Isoliquiritigenin Inhibits Breast Cancer Neoangiogenesis via VEGF/VEGFR-2 Signaling Pathway
Zhiyu Wang,Neng Wang,Shouwei Han,Dongmei Wang,Sui-Lin Mo,Linzhong Yu,Hui Huang,Kamchuen Tsui,Jiangang Shen,Jianping Chen +9 more
TL;DR: This study found that ISL significantly inhibited the VEGF-induced proliferation of human umbilical vein endothelial cells (HUVECs) at non-toxic concentration and shed light on the potential application of ISL as a novel natural inhibitor for cancer angiogenesis via the V EGF/VEGFR-2 pathway.