J
Jiangang Shen
Researcher at University of Hong Kong
Publications - 179
Citations - 8185
Jiangang Shen is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Neuroprotection & Peroxynitrite. The author has an hindex of 45, co-authored 167 publications receiving 5777 citations. Previous affiliations of Jiangang Shen include Guangzhou University & Academia Sinica.
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Journal ArticleDOI
Dioscin induces cancer cell apoptosis through elevated oxidative stress mediated by downregulation of peroxiredoxins
Zhiyu Wang,Yue Cheng,Neng Wang,Dongmei Wang,Ying Wei Li,Feng Han,Jiangang Shen,Depo Yang,Xin Yuan Guan,Jianping Chen +9 more
TL;DR: It is suggested that PRDX1 and PRDX6 are key targets in the process of dioscin-induced apoptosis that involves intracellular elevated ROS.
Journal ArticleDOI
Glycyrrhizin Prevents Hemorrhagic Transformation and Improves Neurological Outcome in Ischemic Stroke with Delayed Thrombolysis Through Targeting Peroxynitrite-Mediated HMGB1 Signaling
Hansen Chen,Binghe Guan,Bin Wang,Haiwei Pu,Xiaoyu Bai,Xi Chen,Jihong Liu,Caiming Li,Jinhua Qiu,Dan Yang,Kejian Liu,Qi Wang,Suhua Qi,Jiangang Shen,Jiangang Shen +14 more
TL;DR: Glycyrrhizin significantly decreased the mortality rate, attenuated hemorrhagic transformation, brain swelling, blood-brain barrier damage, neuronal apoptosis, and improved neurological outcomes in the ischemic stroke rat model with delayed t-PA treatment.
Journal ArticleDOI
Baicalin promotes neuronal differentiation of neural stem/progenitor cells through modulating p-stat3 and bHLH family protein expression.
TL;DR: The results indicate that baicalin can promote the neural differentiation but inhibit glial formation and its neurogenesis-promoting effects are associated with the modulations of stat3 and bHLH genes in neural stem/progenitor cells.
Journal ArticleDOI
Plasma membrane cholesterol: a possible barrier to intracellular oxygen in normal and mutant CHO cells defective in cholesterol metabolism.
Nadeem Khan,Jiangang Shen,Ta-Yuan Chang,Catherine C. Chang,Peter C. W. Fung,Oleg Y. Grinberg,Eugene Demidenko,Harold Swartz +7 more
TL;DR: The results indicate that the concentration of cholesterol in the plasma membrane can be an important factor for the magnitude of the oxygen gradient observed across the cell membrane.
Journal ArticleDOI
Spatholobus suberectus inhibits cancer cell growth by inducing apoptosis and arresting cell cycle at G2/M checkpoint.
Zhiyu Wang,Dongmei Wang,Tjing Yung Loo,Yue Cheng,Leilei Chen,Jiangang Shen,Depo Yang,Louis Wing-cheong Chow,Xin Yuan Guan,Jianping Chen +9 more
TL;DR: Wang et al. as discussed by the authors investigated the anti-cancer effect of spatholobus suberectus (SS) and its molecular mechanisms, and showed that SS effectively inhibits tumor cell growth in a dosedependent manner.