J
Jianxin Jiang
Researcher at Third Military Medical University
Publications - 15
Citations - 1345
Jianxin Jiang is an academic researcher from Third Military Medical University. The author has contributed to research in topics: Sepsis & Inflammasome. The author has an hindex of 12, co-authored 15 publications receiving 742 citations.
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Journal ArticleDOI
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
Rui Kang,Ling Zeng,Shan Zhu,Yangchun Xie,Jiao Liu,Qirong Wen,Lizhi Cao,Min Xie,Qitao Ran,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Daolin Tang +14 more
TL;DR: It is suggested that lipid peroxidation drives GSDMD-mediated pyroptosis and hence constitutes a potential therapeutic target for lethal infection.
Journal ArticleDOI
PKM2-Dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Min Xie,Yan Yu,Yan Yu,Rui Kang,Shan Zhu,Liangchun Yang,Ling Zeng,Ling Zeng,Xiaofang Sun,Minghua Yang,Timothy R. Billiar,Haichao Wang,Lizhi Cao,Jianxin Jiang,Daolin Tang,Daolin Tang +15 more
TL;DR: It is shown that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages, and an important role of PKM2 in immunometabolism is defined to guide future development of therapeutic strategies to treat sepsi.
Journal ArticleDOI
TMEM173 Drives Lethal Coagulation in Sepsis
Hui Zhang,Ling Zeng,Min Xie,Jiao Liu,Borong Zhou,Runliu Wu,Lizhi Cao,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Herbert J. Zeh,Rui Kang,Jianxin Jiang,Yan Yu,Daolin Tang,Daolin Tang +15 more
TL;DR: The upregulation of the TMEM173 pathway correlates with the severity of disseminated intravascular coagulation and mortality in patients with sepsis and is a key regulator of blood clotting during lethal bacterial infections.
Journal ArticleDOI
The Circadian Clock Controls Immune Checkpoint Pathway in Sepsis
Wenjun Deng,Wenjun Deng,Shan Zhu,Ling Zeng,Jiao Liu,Rui Kang,Minghua Yang,Lizhi Cao,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Min Xie,Daolin Tang,Daolin Tang +13 more
TL;DR: It is suggested that the circadian clock controls the immune checkpoint pathway in macrophages and therefore represents a potential therapeutic target for lethal infection.
Journal ArticleDOI
ALK is a therapeutic target for lethal sepsis.
Ling Zeng,Ling Zeng,Ling Zeng,Rui Kang,Shan Zhu,Xiao Wang,Lizhi Cao,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Daolin Tang +11 more
TL;DR: Evidence is provided to support a role for anaplastic lymphoma kinase (ALK), a tumor-associated receptor tyrosine kinase, in the regulation of innate immunity during lethal sepsis, and a key role for ALK in modulating the inflammatory signaling pathway is uncovered.