Borong Zhou

TL;DR: Current knowledge on the signaling pathways involved in ferroptosis is summarized, while focusing on the regulation of autophagy-dependent ferroptic cell death, which may lead to the development of novel anticancer therapies.

TL;DR: It is demonstrated that HMGB1 is a DAMP released by ferroptotic cells in an autophagy-dependent manner, and studies suggest thatHMGB1 inhibition might have some potential therapeutic effects in ferroPTosis-associated human disease.

TL;DR: The upregulation of the TMEM173 pathway correlates with the severity of disseminated intravascular coagulation and mortality in patients with sepsis and is a key regulator of blood clotting during lethal bacterial infections.

TL;DR: An impaired PINK1-PARK2-mediated neuroimmunology pathway contributes to septic death and may represent a novel therapeutic target in critical care medicine.

TL;DR: CDK1/2/5 inhibition by dinaciclib provides a novel strategy to overcome IFNG-triggered acquired resistance in pancreatic tumour immunity.