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Shan Zhu
Researcher at Guangzhou Medical University
Publications - 31
Citations - 2716
Shan Zhu is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 16 publications receiving 1453 citations.
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Journal ArticleDOI
The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity
Yangchun Xie,Yangchun Xie,Yangchun Xie,Shan Zhu,Xinxin Song,Xiaofang Sun,Yong Fan,Jinbao Liu,Meizuo Zhong,Hua Yuan,Lin Zhang,Timothy R. Billiar,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Guido Kroemer,Daolin Tang,Daolin Tang +17 more
TL;DR: Findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.
Journal ArticleDOI
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity.
Xinxin Song,Xinxin Song,Shan Zhu,Pan Chen,Wen Hou,Qirong Wen,Jiao Liu,Yangchun Xie,Yangchun Xie,Jinbao Liu,Daniel J. Klionsky,Guido Kroemer,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Daolin Tang,Daolin Tang +16 more
TL;DR: It is shown that BECN1 plays a hitherto unsuspected role in promoting ferroptosis through directly blocking system Xc- activity via binding to its core component, SLC7A11 (solute carrier family 7 member 11).
Journal ArticleDOI
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
Rui Kang,Ling Zeng,Shan Zhu,Yangchun Xie,Jiao Liu,Qirong Wen,Lizhi Cao,Min Xie,Qitao Ran,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Daolin Tang +14 more
TL;DR: It is suggested that lipid peroxidation drives GSDMD-mediated pyroptosis and hence constitutes a potential therapeutic target for lethal infection.
Journal ArticleDOI
PKM2-Dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Min Xie,Yan Yu,Yan Yu,Rui Kang,Shan Zhu,Liangchun Yang,Ling Zeng,Ling Zeng,Xiaofang Sun,Minghua Yang,Timothy R. Billiar,Haichao Wang,Lizhi Cao,Jianxin Jiang,Daolin Tang,Daolin Tang +15 more
TL;DR: It is shown that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages, and an important role of PKM2 in immunometabolism is defined to guide future development of therapeutic strategies to treat sepsi.
Journal ArticleDOI
HSPA5 Regulates Ferroptotic Cell Death in Cancer Cells.
TL;DR: It is shown that heatshock 70-kDa protein 5 (HSPA5) negatively regulates ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cells, and a potential therapeutic strategy for overcoming gemcitabine resistance is suggested.