J
Jiao Liu
Researcher at Guangzhou Medical University
Publications - 66
Citations - 4551
Jiao Liu is an academic researcher from Guangzhou Medical University. The author has contributed to research in topics: Medicine & Programmed cell death. The author has an hindex of 19, co-authored 46 publications receiving 1659 citations.
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Journal ArticleDOI
Ferroptosis is a type of autophagy-dependent cell death.
TL;DR: Current knowledge on the signaling pathways involved in ferroptosis is summarized, while focusing on the regulation of autophagy-dependent ferroptic cell death, which may lead to the development of novel anticancer therapies.
Journal ArticleDOI
AMPK-Mediated BECN1 Phosphorylation Promotes Ferroptosis by Directly Blocking System Xc- Activity.
Xinxin Song,Xinxin Song,Shan Zhu,Pan Chen,Wen Hou,Qirong Wen,Jiao Liu,Yangchun Xie,Yangchun Xie,Jinbao Liu,Daniel J. Klionsky,Guido Kroemer,Michael T. Lotze,Herbert J. Zeh,Rui Kang,Daolin Tang,Daolin Tang +16 more
TL;DR: It is shown that BECN1 plays a hitherto unsuspected role in promoting ferroptosis through directly blocking system Xc- activity via binding to its core component, SLC7A11 (solute carrier family 7 member 11).
Journal ArticleDOI
Lipid Peroxidation Drives Gasdermin D-Mediated Pyroptosis in Lethal Polymicrobial Sepsis
Rui Kang,Ling Zeng,Shan Zhu,Yangchun Xie,Jiao Liu,Qirong Wen,Lizhi Cao,Min Xie,Qitao Ran,Guido Kroemer,Haichao Wang,Timothy R. Billiar,Jianxin Jiang,Daolin Tang,Daolin Tang +14 more
TL;DR: It is suggested that lipid peroxidation drives GSDMD-mediated pyroptosis and hence constitutes a potential therapeutic target for lethal infection.
Journal ArticleDOI
Autophagy-Dependent Ferroptosis: Machinery and Regulation
TL;DR: In this article, the role of autophagy, especially selective types, in driving cells toward ferroptotic death was explored and the functional interactions between metabolism, immunity, and cell death were explored.
Journal ArticleDOI
The release and activity of HMGB1 in ferroptosis
TL;DR: It is demonstrated that HMGB1 is a DAMP released by ferroptotic cells in an autophagy-dependent manner, and studies suggest thatHMGB1 inhibition might have some potential therapeutic effects in ferroPTosis-associated human disease.