J
Jihwan Myung
Researcher at Taipei Medical University
Publications - 29
Citations - 1106
Jihwan Myung is an academic researcher from Taipei Medical University. The author has contributed to research in topics: Circadian clock & Circadian rhythm. The author has an hindex of 13, co-authored 28 publications receiving 860 citations. Previous affiliations of Jihwan Myung include Kyoto University & Humboldt University of Berlin.
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Journal ArticleDOI
Genome-Wide Profiling of the Core Clock Protein BMAL1 Targets Reveals a Strict Relationship with Metabolism
Fumiyuki Hatanaka,Chiaki Matsubara,Jihwan Myung,Jihwan Myung,Jihwan Myung,Takashi Yoritaka,Naoko Kamimura,Shuichi Tsutsumi,Akinori Kanai,Yutaka Suzuki,Paolo Sassone-Corsi,Hiroyuki Aburatani,Sumio Sugano,Toru Takumi +13 more
TL;DR: It is revealed that, in addition to E-boxes, the CCAATG element contributes to elicit robust circadian expression and is a useful resource to decipher the network of circadian gene control and its intimate links with several fundamental physiological functions.
Journal ArticleDOI
GABA-mediated repulsive coupling between circadian clock neurons in the SCN encodes seasonal time
Jihwan Myung,Jihwan Myung,Sungho Hong,Daniel DeWoskin,Erik De Schutter,Daniel B. Forger,Toru Takumi,Toru Takumi +7 more
TL;DR: It is shown that increasing day-length changes the pattern of chloride transporter expression, yielding more excitatory GABA synaptic input, and that blocking GABAA signaling or the chloride transporter disrupts the unique phase and period organization induced by the day length.
Journal ArticleDOI
A novel protein, CHRONO, functions as a core component of the mammalian circadian clock.
Akihiro Goriki,Fumiyuki Hatanaka,Jihwan Myung,Jae Kyoung Kim,Takashi Yoritaka,Shintaro Tanoue,Takaya Abe,Hiroshi Kiyonari,Katsumi Fujimoto,Yukio Kato,Takashi Todo,Akio Matsubara,Daniel B. Forger,Toru Takumi +13 more
TL;DR: Two independent studies, one of them using a computational approach, identified CHRONO, a gene shown to modulate the activity of circadian transcription factors and alter circadian behavior in mice.
Journal ArticleDOI
Distinct roles for GABA across multiple timescales in mammalian circadian timekeeping.
TL;DR: This work proposes the existence of two types of differentially regulated GABA signaling—fast signaling that regulates neuronal output, and slow signaling that modulates synchrony between neurons—a hypothesis that can explain many previous experimental results and provides an important tool for circadian research.
Journal ArticleDOI
The choroid plexus is an important circadian clock component.
Jihwan Myung,Christoph Schmal,Sungho Hong,Yoshiaki Tsukizawa,Pia Rose,Yong Zhang,Michael J. Holtzman,Erik De Schutter,Hanspeter Herzel,Grigory Bordyugov,Toru Takumi,Toru Takumi +11 more
TL;DR: It is demonstrated that the choroid plexus displays oscillations more robust than the SCN and that can be described as a Poincaré oscillator with negative twist, thus finely tuning behavioral circadian rhythms.