J
Jin Li
Researcher at University of California, Davis
Publications - 19
Citations - 315
Jin Li is an academic researcher from University of California, Davis. The author has contributed to research in topics: Small molecule & Drug discovery. The author has an hindex of 8, co-authored 18 publications receiving 203 citations. Previous affiliations of Jin Li include Second Military Medical University.
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Journal ArticleDOI
RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype.
Demin Cai,Junjian Wang,Bei Gao,Jin Li,Feng Wu,June X. Zou,Jianzhen Xu,Yuqian Jiang,Hongye Zou,Zenghong Huang,Alexander D. Borowsky,Richard J. Bold,Primo N. Lara,Jian Jian Li,Xinbin Chen,Kit S. Lam,Ka Fai To,Hsing Jien Kung,Oliver Fiehn,Ruqian Zhao,Ronald M. Evans,Hongwu Chen +21 more
TL;DR: The nuclear receptor RORγ is identified as a novel master regulator of cholesterol metabolism in triple negative breast cancer (TNBC) and small-molecule antagonists induce tumor regression in patient-derived xenografts and immunocompetent mouse models.
Journal ArticleDOI
Double-edged swords as cancer therapeutics: novel, orally active, small molecules simultaneously inhibit p53-MDM2 interaction and the NF-κB pathway.
Chunlin Zhuang,Zhenyuan Miao,Yuelin Wu,Zizhao Guo,Jin Li,Jianzhong Yao,Chengguo Xing,Chunquan Sheng,Wannian Zhang +8 more
TL;DR: A proof-of-concept study that p53-MDM2 interaction and NF-κB pathway can be simultaneously targeted by a small-molecule inhibitor is provided.
Journal ArticleDOI
Design, synthesis and biological activity of piperlongumine derivatives as selective anticancer agents.
Yuelin Wu,Xiao Min,Chunlin Zhuang,Jin Li,Zhiliang Yu,Guoqiang Dong,Jiangzhong Yao,Shengzheng Wang,Yang Liu,Shanchao Wu,Shiping Zhu,Chunquan Sheng,Yunyang Wei,Huojun Zhang,Wannian Zhang,Zhenyuan Miao +15 more
TL;DR: The results indicated that halogen substituents as electrophilic group at C2 played an important role in increasing cytotoxicity.
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Single Small Molecule‐Assembled Mitochondria Targeting Nanofibers for Enhanced Photodynamic Cancer Therapy In Vivo
Kai Lin,Kai Lin,Zhao Ma,Jin Li,Menghuan Tang,Aaron Lindstrom,Mythili Ramachandran,Shaoming Zhu,Tzu-yin Lin,Lanwei Zhang,Yuanpei Li +10 more
TL;DR: A fiber‐forming nanophotosensitizer (PQC NF) that is composed of mitochondria targeting small molecules of amphiphilicity offers an advantageous strategy to improve the in vivo therapeutic effects of conventional PDT.
Journal ArticleDOI
Pharmacophore hybridisation and nanoscale assembly to discover self-delivering lysosomotropic new-chemical entities for cancer therapy
Zhao Ma,Zhao Ma,Jin Li,Kai Lin,Mythili Ramachandran,Dalin Zhang,Megan R. Showalter,Cristabelle De Souza,Aaron Lindstrom,Lucas N. Solano,Bei Jia,Shiro Urayama,Yuyou Duan,Oliver Fiehn,Tzu-yin Lin,Minyong Li,Yuanpei Li +16 more
TL;DR: These single-drug nanoparticles demonstrate excellent pharmacokinetic and toxicological profiles and dramatic antitumour efficacy in vivo and are thus promising agents for autophagy inhibition-based combination therapy.