M
Megan R. Showalter
Researcher at University of California, Davis
Publications - 29
Citations - 1747
Megan R. Showalter is an academic researcher from University of California, Davis. The author has contributed to research in topics: Metabolome & Metabolomics. The author has an hindex of 14, co-authored 27 publications receiving 1088 citations. Previous affiliations of Megan R. Showalter include University of California, Berkeley.
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Journal ArticleDOI
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition
Henrik Sperber,Julie Mathieu,Yuliang Wang,Amy Ferreccio,Jennifer Hesson,Zhuojin Xu,Karin A. Fischer,Arikketh Devi,Arikketh Devi,Damien Detraux,Haiwei Gu,Stephanie L. Battle,Megan R. Showalter,Cristina Valensisi,Jason H. Bielas,Jason H. Bielas,Nolan G. Ericson,Lilyana Margaretha,Aaron M. Robitaille,Daciana Margineantu,Oliver Fiehn,Oliver Fiehn,David M. Hockenbery,C. Anthony Blau,Daniel Raftery,Daniel Raftery,Adam A. Margolin,R. David Hawkins,Randall T. Moon,Randall T. Moon,Carol B. Ware,Hannele Ruohola-Baker +31 more
TL;DR: It is shown that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in human embryonic stem cells (hESCs), supporting the hypothesis that the metabolome regulates the epigenetic landscape of the earliest steps in human development.
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Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics
Zijuan Lai,Hiroshi Tsugawa,Gert Wohlgemuth,Sajjan S. Mehta,Matthew Mueller,Yuxuan Zheng,Atsushi Ogiwara,John K. Meissen,Megan R. Showalter,Kohei Takeuchi,Tobias Kind,Peter A. Beal,Masanori Arita,Oliver Fiehn,Oliver Fiehn +14 more
TL;DR: This work annotates N- methyl-uridine monophosphate, lysomonogalactosyl-monopalmitin, N-methylalanine, and two propofol derivatives using a combination of 14 metabolome databases in addition to an enzyme promiscuity library.
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Identification of small molecules using accurate mass MS/MS search.
Tobias Kind,Hiroshi Tsugawa,Tomas Cajka,Yan Ma,Zijuan Lai,Sajjan S. Mehta,Gert Wohlgemuth,Dinesh Kumar Barupal,Megan R. Showalter,Masanori Arita,Oliver Fiehn,Oliver Fiehn +11 more
TL;DR: Parameters that influence search results, such as mass accuracy, precursor ion isolation width, intensity thresholds, centroiding algorithms, and acquisition speed are critically discussed.
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Structure Annotation of All Mass Spectra in Untargeted Metabolomics
Ivana Blaženović,Tobias Kind,Michael R. Sa,Jian Ji,Arpana Vaniya,Benjamin Wancewicz,Bryan S. Roberts,Hrvoje Torbašinović,Tack Lee,Sajjan S. Mehta,Megan R. Showalter,Hosook Song,Jessica Kwok,Dieter Jahn,Jayoung Kim,Oliver Fiehn +15 more
TL;DR: All metabolites detected by two untargeted metabolomic assays, hydrophilic interaction chromatography and Exactive HF mass spectrometry, are annotated using the in silico fragmentation tool CSI:FingerID and the new NIST hybrid search to annotate all further compounds (MSI level 3.
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TFPa/HADHA is required for fatty acid beta-oxidation and cardiolipin re-modeling in human cardiomyocytes.
Jason W. Miklas,Elisa C. Clark,Shiri Levy,Damien Detraux,Andrea Leonard,Kevin M. Beussman,Megan R. Showalter,Alec S.T. Smith,Peter Hofsteen,Xiulan Yang,Jesse Macadangdang,Tuula Manninen,Daniel Raftery,Anup Madan,Anu Suomalainen,Deok Ho Kim,Charles E. Murry,Oliver Fiehn,Oliver Fiehn,Nathan J. Sniadecki,Yuliang Wang,Hannele Ruohola-Baker +21 more
TL;DR: It is shown that the MTP deficient pathology in human cardiomyocytes leads to an abnormal cardiolipin pattern and suggests that cardiolIPin affecting compounds may serve as a potential therapy.