J
Jin-Soo Kim
Researcher at Seoul National University
Publications - 308
Citations - 26566
Jin-Soo Kim is an academic researcher from Seoul National University. The author has contributed to research in topics: CRISPR & Genome editing. The author has an hindex of 66, co-authored 264 publications receiving 21375 citations. Previous affiliations of Jin-Soo Kim include UPRRP College of Natural Sciences & Korea University of Science and Technology.
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Journal ArticleDOI
Digenome-seq web tool for profiling CRISPR specificity.
Jeongbin Park,Liam Childs,Daesik Kim,Gue Ho Hwang,Sung-Hyun Kim,Sangtae Kim,Jin-Soo Kim,Sangsu Bae +7 more
TL;DR: A redesigned analysis tool for Digenome-seq data that runs on web browsers is presented, which can instantly perform the complete analysis in an ordinary web browser with fast execution speed without uploading any data to a server and without local tool installation.
Journal ArticleDOI
Artificial transcription factors increase production of recombinant antibodies in Chinese hamster ovary cells.
Ryuk-Jun Kwon,Seong Keun Kim,Seung-Il Lee,Su-Jeong Hwang,Gyun Min Lee,Jin-Soo Kim,Wongi Seol +6 more
TL;DR: It is shown that ZFP-TF libraries can be used to identify components that improve antibody production in CHO cells and a mutated version of LK52, however, did not boost mAb-72 production.
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Identification and use of zinc finger transcription factors that increase production of recombinant proteins in yeast and mammalian cells.
Kyung-Soon Park,O Wongi Seol,O Hyo-Young Yang,Seong-Il Lee,Sung Keun Kim,Ryuk Jun Kwon,Eui-Joong Kim,Young Hoon Roh,Baik Lin Seong,Jin-Soo Kim +9 more
TL;DR: The results show that randomized ZFP‐TF libraries are useful tools for improving the yield of heterologous recombinant protein both in yeast and mammalian cells.
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CRISPR-Pass: Gene Rescue of Nonsense Mutations Using Adenine Base Editors.
C.-K. Lee,Dong Hyun Jo,Gue Ho Hwang,Jihyeon Yu,Jin Hyoung Kim,Se eun Park,Jin-Soo Kim,Jeong Hun Kim,Jeong Hun Kim,Sangsu Bae +9 more
TL;DR: CRISPR-pass, which should be applicable to 95.5% of clinically significant nonsense mutations in the ClinVar database, rescues protein synthesis in patient-derived fibroblasts, suggesting potential clinical utility.
Journal ArticleDOI
Analysis of the effect of aging on the response to hypoxia by cDNA microarray.
TL;DR: Of 7458 genes in the microarray, it is found that genes involved in angiogenesis, defense against oxidative stress, and transcription regulation are severely impaired in senescent cell, which is consistent with the fact that aged cells have attenuated responses to various stimuli.