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Jin-Soo Kim

Researcher at Seoul National University

Publications -  308
Citations -  26566

Jin-Soo Kim is an academic researcher from Seoul National University. The author has contributed to research in topics: CRISPR & Genome editing. The author has an hindex of 66, co-authored 264 publications receiving 21375 citations. Previous affiliations of Jin-Soo Kim include UPRRP College of Natural Sciences & Korea University of Science and Technology.

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Journal ArticleDOI

Genome-wide target specificity of CRISPR RNA-guided adenine base editors.

Daesik Kim, +5 more
- 04 Mar 2019 - 
TL;DR: A modified version of Digenome-seq is presented, an in vitro method for identifying CRISPR (clustered regularly interspaced short palindromic repeats)-induced double-strand breaks using whole-genome sequencing to assess genome-wide target specificity of adenine base editors.
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Targeted inversion and reversion of the blood coagulation factor 8 gene in human iPS cells using TALENs

Chul-Yong Park, +9 more
- 24 Jun 2014 - 
TL;DR: It is shown that TALENs can be used both for creating disease models associated with chromosomal rearrangements in iPSCs and for correcting genetic defects caused by chromosomal inversions, as an iPSC-based novel therapeutic option for the treatment of hemophilia A.
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Surrogate reporter-based enrichment of cells containing RNA-guided Cas9 nuclease-induced mutations.

Suresh Ramakrishna, +6 more
- 26 Feb 2014 - 
TL;DR: Efficient methods to enrich cells containing RGEN-induced mutations by using surrogate reporters are reported, envisioning that these reporters will facilitate the use of RGEN in a wide range of biomedical research.
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Genome surgery using Cas9 ribonucleoproteins for the treatment of age-related macular degeneration

Kyoungmi Kim, +10 more
- 01 Mar 2017 - 
TL;DR: The results demonstrate that in vivo genome editing with Cas9 RNPs has the potential for the local treatment for nongenetic degenerative diseases, expanding the scope of RNA-guided genome surgery to a new dimension.
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Efficient delivery of nuclease proteins for genome editing in human stem cells and primary cells

Jia Liu, +8 more
- 01 Nov 2015 - 
TL;DR: Protocols for the expression, purification and delivery of ZFN proteins, which are intrinsically cell-permeable; TALEN proteins, whose nucleofection into cells facilitates rapid induction of multiplexed modifications, are described, along with procedures for evaluating nuclease protein activity.