J
Jing Tu
Researcher at Leiden University
Publications - 15
Citations - 548
Jing Tu is an academic researcher from Leiden University. The author has contributed to research in topics: Mesoporous silica & Lipid bilayer. The author has an hindex of 10, co-authored 13 publications receiving 454 citations. Previous affiliations of Jing Tu include Xiamen University.
Papers
More filters
Journal ArticleDOI
Multifunctional ZnPc-loaded mesoporous silica nanoparticles for enhancement of photodynamic therapy efficacy by endolysosomal escape.
TL;DR: A strategy for enhancement of PDT efficacy by endolysosomal escape is presented and the promise of using multifunctional MSNs for cancer therapy is highlighted.
Journal ArticleDOI
Mesoporous Silica Nanoparticles with Large Pores for the Encapsulation and Release of Proteins
Jing Tu,Aimee L. Boyle,Heiner Friedrich,Phh Paul Bomans,Jeroen Bussmann,Nico A. J. M. Sommerdijk,Wim Jiskoot,Alexander Kros +7 more
TL;DR: These MSNs with their large surface area and optimal dimensions provide a scaffold with a high encapsulation efficiency and controllable release profiles for a variety of proteins, enabling potential applications in fields such as drug delivery and protein therapy.
Journal ArticleDOI
Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.
Guangsheng Du,Rania M. Hathout,Maha Nasr,M. Reza Nejadnik,Jing Tu,Roman I. Koning,Abraham J. Koster,Bram Slütter,Alexander Kros,Wim Jiskoot,Joke A. Bouwstra,Juha Mönkäre +11 more
TL;DR: The applicator controlled hollow microneedle delivery is an excellent method for intradermal injection of nanoparticle vaccines, allowing selection of optimal nanoparticle formulations for humoral and cellular immune responses.
Journal ArticleDOI
Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles.
TL;DR: C cuboidal mesoporous silica nanoparticles containing disk‐shaped cavities with a large pore diameter (10 nm) are studied as a protein delivery vehicle using cytochrome‐c (cytC) as a model membrane‐impermeable protein to suggest a universal way for the efficient delivery of any type of inorganic nanoparticle or protein into cells mediated by CC induced membrane fusion.
Journal ArticleDOI
Mesoporous Silica Nanoparticle-Coated Microneedle Arrays for Intradermal Antigen Delivery.
Jing Tu,Guangsheng Du,M. Reza Nejadnik,Juha Mönkäre,Koen van der Maaden,Paul H. H. Bomans,Nico A. J. M. Sommerdijk,Bram Slütter,Wim Jiskoot,Joke A. Bouwstra,Alexander Kros +10 more
TL;DR: Microneedle arrays coated with LB-MSN-OVA were successfully developed and shown to be suitable for intradermal delivery of the encapsulated protein antigen.