Intradermal vaccination with hollow microneedles: A comparative study of various protein antigen and adjuvant encapsulated nanoparticles.
Guangsheng Du,Rania M. Hathout,Maha Nasr,M. Reza Nejadnik,Jing Tu,Roman I. Koning,Abraham J. Koster,Bram Slütter,Alexander Kros,Wim Jiskoot,Joke A. Bouwstra,Juha Mönkäre +11 more
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TLDR
The applicator controlled hollow microneedle delivery is an excellent method for intradermal injection of nanoparticle vaccines, allowing selection of optimal nanoparticle formulations for humoral and cellular immune responses.About:
This article is published in Journal of Controlled Release.The article was published on 2017-11-28 and is currently open access. It has received 103 citations till now. The article focuses on the topics: PLGA.read more
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Biodegradable 3D printed polymer microneedles for transdermal drug delivery.
Michael A. Luzuriaga,Danielle R. Berry,John C. Reagan,Ronald A. Smaldone,Jeremiah J. Gassensmith +4 more
TL;DR: This work presents a new microfabrication technique for MNs using fused deposition modeling (FDM) 3D printing using polylactic acid, an FDA approved, renewable, biodegradable, thermoplastic material, and demonstrates how the swellability of PLA can be exploited to load small molecule drugs and how its degradability in skin can release those small molecules over time.
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Recent advances of microneedles for biomedical applications: drug delivery and beyond.
TL;DR: In this review, a great effort has been made to summarize the advance of microneedles including their materials and latest fabrication method, such as three-dimensional printing (3DP).
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Biomaterials for vaccine-based cancer immunotherapy.
TL;DR: The rational design and clinical status of several classes of cancer vaccines are discussed along with novel biomaterial‐based delivery technologies that improve their safety and efficacy.
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Glucose- and H2O2-Responsive Polymeric Vesicles Integrated with Microneedle Patches for Glucose-Sensitive Transcutaneous Delivery of Insulin in Diabetic Rats
Zaizai Tong,Junyi Zhou,Jiaxing Zhong,Qiuju Tang,Zhentao Lei,Haipeng Luo,Pianpian Ma,Xiangdong Liu +7 more
TL;DR: The transdermal delivery of insulin to the diabetic rats ((insulin + GO x)-loaded MNs) presents an effective hypoglycemic effect compared to that of subcutaneous injection or only insulin- loaded MNs, which indicates the as-prepared MNs insulin delivery system could be of great importance for the applications in the therapy of diabetes.
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Intradermal delivery of vaccine nanoparticles using hollow microneedle array generates enhanced and balanced immune response.
TL;DR: The results show that hollow microneedle mediated intradermal delivery of polymeric NPs is a promising approach to improve the effectiveness of vaccine formulations.
References
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Diffusion of Univalent Ions Across the Lamellae of Swollen Phospholipids
TL;DR: It is found that as the surface charge of the lipid lamellae is increased, the amount of cation per μmle of lipid increases, and the phospholipid liquid crystalline structures appear to “bind” or “capture” cations.
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Nanoparticles target distinct dendritic cell populations according to their size
TL;DR: Evidence that particle size determines the mechanism of trafficking to the LN is provided and it is shown that only small nanoparticles can specifically target LN‐resident cells.
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Key roles of adjuvants in modern vaccines
TL;DR: The potential benefits and importance of formulation and mechanisms of action of adjuvants are outlined and safety considerations are emphasized in the clinical development of effective adjuvant that will help facilitate effective next-generation vaccines against devastating infectious diseases.
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Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
TL;DR: A pH gradient is shown, with the most acidic environment at the center of the spheres and higher pH near the edges, which is characteristic of diffusion-controlled release of the acidicdegradation products.
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Protein instability in poly(lactic-co-glycolic acid) microparticles.
TL;DR: The use of various stabilization approaches has rendered some success in increasing protein stability, but, still, full preservation of the native protein structure remains a major challenge in the formulation of protein-loaded PLGA microparticles.