J
Jing Zhao
Researcher at Tufts University
Publications - 7
Citations - 1549
Jing Zhao is an academic researcher from Tufts University. The author has contributed to research in topics: Polyadenylation & RNA. The author has an hindex of 5, co-authored 5 publications receiving 1499 citations.
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Journal ArticleDOI
Formation of mRNA 3′ Ends in Eukaryotes: Mechanism, Regulation, and Interrelationships with Other Steps in mRNA Synthesis
TL;DR: Recent findings suggest that the association of cleavage/polyadenylation factors with the transcriptional complex via the carboxyl-terminal domain of the RNA polymerase II (Pol II) large subunit is the means by which the cell restricts polyadenylations to Pol II transcripts.
Journal ArticleDOI
Hrp1, a sequence-specific RNA-binding protein that shuttles between the nucleus and the cytoplasm, is required for mRNA 3′-end formation in yeast
Marco M. Kessler,Michael F. Henry,Elisa Shen,Jing Zhao,Stefan Gross,Pamela A. Silver,Claire Moore +6 more
TL;DR: The HRP1 gene was originally isolated as a suppressor of a temperature-sensitive npl3 allele, a gene encoding a protein involved in mRNA export, providing a potential link between 3'-end processing and mRNA export from the nucleus.
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Purification of the Saccharomyces cerevisiae cleavage/polyadenylation factor I. Separation into two components that are required for both cleavage and polyadenylation of mRNA 3' ends.
TL;DR: The purification of CF I and its separation into two components, CF IA and CF IB, are described, indicating that RNA14 and RNA15 proteins exist in a tight complex.
Journal ArticleDOI
Pta1, a component of yeast CF II, is required for both cleavage and poly(A) addition of mRNA precursor.
TL;DR: The involvement of Pta1 in both steps of mRNA 3′-end formation supports the conclusion that CF II is the functional homolog of CPSF.
Journal ArticleDOI
Cleavage Factor II of Saccharomyces cerevisiaeContains Homologues to Subunits of the Mammalian Cleavage/ Polyadenylation Specificity Factor and Exhibits Sequence-specific, ATP-dependent Interaction with Precursor RNA
TL;DR: The sequence-specific binding of Cft2 and the similarities of CF II subunits to those of CPSF supports the hypothesis that CF II functions in the cleavage of yeast mRNA 3′-ends in a manner analagous to that of CPSf in the mammalian system.