Jingchun Luo

TL;DR: The authors' findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.

TL;DR: This study provides an effective gene-based approach to association study design and analysis and implicated novel genes, including RAPGEF1 and TP53, in type 2 diabetes susceptibility.

TL;DR: Prostate cancer affects more than 190,000 men each year with ∼10% of men diagnosed at ≤55 years, that is, early onset (EO) PCa, likely reflects a stronger underlying genetic etiology.

TL;DR: This data provide an example of an uncommon variant responsible for a GWA signal and demonstrate that genetic associations with phenotypes measured by antibody-based quantification methods can be affected by uncommon coding SNPs residing in the antibody target region.

TL;DR: Analysis of genome-wide association analyses in China identified multiple loci associated with glycemic traits across China, and suggest a regulatory mechanism at the SIX3-SIX2 fasting glucose GWAS locus.