W
Wanda K. O'Neal
Researcher at University of North Carolina at Chapel Hill
Publications - 199
Citations - 12588
Wanda K. O'Neal is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: COPD & Medicine. The author has an hindex of 52, co-authored 160 publications receiving 9990 citations. Previous affiliations of Wanda K. O'Neal include Cornell University & Baylor College of Medicine.
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Journal ArticleDOI
SARS-CoV-2 Reverse Genetics Reveals a Variable Infection Gradient in the Respiratory Tract.
Yixuan J. Hou,Kenichi Okuda,Caitlin E. Edwards,David R. Martinez,Takanori Asakura,Kenneth H. Dinnon,Takafumi Kato,Rhianna E. Lee,Boyd Yount,Teresa M. Mascenik,Gang Chen,Kenneth N. Olivier,Andrew J. Ghio,Longping V. Tse,Sarah R. Leist,Lisa E. Gralinski,Alexandra Schäfer,Hong Dang,Rodney C. Gilmore,Satoko Nakano,Ling Sun,M. Leslie Fulcher,Alessandra Livraghi-Butrico,Nathan I. Nicely,Mark J. Cameron,Cheryl M. Cameron,David J. Kelvin,David J. Kelvin,Aravinda M. de Silva,David M. Margolis,Alena J. Markmann,Luther A. Bartelt,Ross E. Zumwalt,Fernando J. Martinez,Steven P. Salvatore,Alain C. Borczuk,Purushothama Rao Tata,Vishwaraj Sontake,Adam J. Kimple,Ilona Jaspers,Wanda K. O'Neal,Scott H. Randell,Richard C. Boucher,Ralph S. Baric +43 more
TL;DR: The nasal susceptibility to SARS-CoV-2 with likely subsequent aspiration-mediated virus seeding to the lung in SARS/COVID-19 pathogenesis is highlighted and reagents provide a foundation for investigations into virus-host interactions in protective immunity, host susceptibility, and virus pathogenesis.
Journal ArticleDOI
Increased airway epithelial Na+ absorption produces cystic fibrosis-like lung disease in mice.
TL;DR: It is concluded that increasing airway Na+ absorption initiates cystic fibrosis-like lung disease and produces a model for the study of the pathogenesis and therapy of this disease.
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Muc5b is required for airway defence
Michelle G. Roy,Alessandra Livraghi-Butrico,Ashley A. Fletcher,Melissa M. McElwee,Scott E. Evans,Ryan M. Boerner,Samantha N. Alexander,Lindsey K. Bellinghausen,Alfred S. Song,Youlia Petrova,Michael J. Tuvim,Roberto Adachi,Irlanda Romo,Andrea S. Bordt,M. Gabriela Bowden,M. Gabriela Bowden,Joseph H. Sisson,Prescott G. Woodruff,David J. Thornton,Karine Rousseau,Maria Miguelina De La Garza,Seyed Javad Moghaddam,Harry Karmouty-Quintana,Michael R. Blackburn,Scott M. Drouin,C. William Davis,Kristy A. Terrell,Barbara R. Grubb,Wanda K. O'Neal,Sonia C. Flores,Adela Cota-Gomez,Catherine A. Lozupone,Jody Donnelly,Alan M. Watson,Corinne E. Hennessy,Rebecca C. Keith,Ivana V. Yang,Lea Barthel,Peter M. Henson,William J. Janssen,David A. Schwartz,Richard C. Boucher,Burton F. Dickey,Christopher M. Evans,Christopher M. Evans +44 more
TL;DR: It is shown that mouse Muc5b (but not MUC5ac) is required for MCC, for controlling infections in the airways and middle ear, and for maintaining immune homeostasis in mouse lungs, whereas Muc 5ac is dispensable.
Journal ArticleDOI
Administration of helper-dependent adenoviral vectors and sequential delivery of different vector serotype for long-term liver-directed gene transfer in baboons
Núria Morral,Wanda K. O'Neal,Karen Rice,Michele Leland,Johanne Kaplan,Pedro A. Piedra,Heshan Zhou,Robin J. Parks,Rizwan Velji,Estuardo Aguilar-Cordova,Samuel C. Wadsworth,Frank L. Graham,Stefan Kochanek,K. Dee Carey,Arthur L. Beaudet +14 more
TL;DR: The duration of expression of AdSTK109 in the liver of baboons and compared it to first-generation vectors expressing hAAT are examined to suggest that long-term expression of transgenes should be possible by combining the reduced immunogenicity and toxicity of helper-dependent vectors with sequential delivery of vectors of different serotypes.
Journal ArticleDOI
Defects in yolk sac vasculogenesis, chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65.
Elizabeth M. Morin-Kensicki,Brian N. Boone,Michael Howell,Jaclyn R. Stonebraker,Jeremy Teed,James G. Alb,Terry Magnuson,Wanda K. O'Neal,Sharon L. Milgram +8 more
TL;DR: In vivo requirements for YAP are revealed in the developmental processes of yolk sac vasculogenesis, chorioallantoic attachment, and embryonic axis elongation.