Jitka Cejkova

TL;DR: H2 solution favorably influenced corneal healing after alkali injury via suppression of oxidative stress, and the expression of proinflammatory cytokines, peroxynitrite, detected by nitrotyrosine residues (NT), and malondialdehyde expressions were very low or absent compared to PBS treated injured corneas, where NT and MDA expressions were present.

TL;DR: The study provides the first evidence of the role of H2 in prevention of oxidative and nitrosative stress in UVB irradiated corneas, which may represent a novel prophylactic approach to corneal photodamage.

TL;DR: Repeated irradiation of the rabbit eye with UV rays of 312 nm wavelength (UVB) evoked the appearance of active plasminogen activator of urokinase type (u-PA) in the anterior eye segment and active u-PA was found in the tear fluid and aqueous humour.

TL;DR: It is demonstrated that trehalose of 3% or 6% concentration in eye drops directly decreases oxidative stress in UVB-irradiated corneas, by removing the excessive amount of reactive oxygen species (ROS), leading to the suppression of oxidative stress and favorable corneal healing.

TL;DR: In conclusion, actinoquinol‐hyaluronic acid eye drops decreased changes in corneal optics and suppressed oxidative damage in the UVB‐irradiated cornea, however, the effectiveCorneal protection by these eye drops was limited to the lower UVB dose.