J
Jiujiu Yu
Researcher at University of Nebraska–Lincoln
Publications - 29
Citations - 4187
Jiujiu Yu is an academic researcher from University of Nebraska–Lincoln. The author has contributed to research in topics: Inflammasome & Histone deacetylase 2. The author has an hindex of 18, co-authored 27 publications receiving 3331 citations. Previous affiliations of Jiujiu Yu include Harvard University & Tsinghua University.
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Journal ArticleDOI
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Jintang Du,Yeyun Zhou,Xiaoyang Su,Jiujiu Yu,Saba Khan,Hong Jiang,Jungwoo Kim,Jimin Woo,Jun Huyn Kim,Brian Hyun Choi,Bin He,Wei Chen,Sheng Zhang,Richard A. Cerione,Johan Auwerx,Quan Hao,Quan Hao,Hening Lin +17 more
TL;DR: It is found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro and may represent a posttranslational modification that can be reversed by Sirt 5 in vivo.
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Critical role for calcium mobilization in activation of the NLRP3 inflammasome
Tomohiko Murakami,Johan Öckinger,Jiujiu Yu,Vanessa Byles,Aisleen McColl,Aldebaran M. Hofer,Tiffany Horng +6 more
TL;DR: It is demonstrated that blockingCa2+ mobilization inhibits assembly and activation of the NLRP3 inflammasome complex, and that during ATP stimulation Ca2+ signaling is pivotal in promoting mitochondrial damage.
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Inflammasome activation leads to Caspase-1–dependent mitochondrial damage and block of mitophagy
Jiujiu Yu,Hajime Nagasu,Tomohiko Murakami,Hai Hoang,Lori Broderick,Hal M. Hoffman,Tiffany Horng +6 more
TL;DR: The role of mitochondrial damage is characterized during activation of the inflammasome pathway, of relevance to host defense and other physiological and pathophysiological settings, and it is shown that activation of this pathway leads to induction of mitochondrialDamage and dismantling of the organelle.
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Akt-mTORC1 signaling regulates Acly to integrate metabolic input to control of macrophage activation
Anthony J. Covarrubias,Halil Ibrahim Aksoylar,Jiujiu Yu,Nathaniel W. Snyder,Nathaniel W. Snyder,Andrew J. Worth,Shankar S. Iyer,Jiawei Wang,Issam Ben-Sahra,Vanessa Byles,Tiffany Polynne-Stapornkul,Erika C Espinosa,Dudley W. Lamming,Brendan D. Manning,Yijing Zhang,Ian A. Blair,Tiffany Horng +16 more
TL;DR: It is proposed that Akt-mTORC1 signaling calibrates metabolic state to energetically demanding aspects of M2 activation, which may define a new role for metabolism in supporting macrophage activation.
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A SANT motif in the SMRT corepressor interprets the histone code and promotes histone deacetylation
TL;DR: It is shown that the second SANT motif functions as part of a histone interaction domain (HID), which implies that the SMRT HID participates in interpreting the histone code in a feed‐forward mechanism that promotes and maintains histone deacetylation at genomic sites of SMRT recruitment.