Jungwoo Kim

TL;DR: It is found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro and may represent a posttranslational modification that can be reversed by Sirt 5 in vivo.

TL;DR: Biophysical insights are provided into how BRAF mutant melanoma cells adapt to the stress of MAPK inhibition via a series of reversible phenotypic transitions toward drug-tolerant or drug-resistant cell states enriched for neural-crest factors and mesenchymal signatures.

TL;DR: Single-cell phosphoproteomics is performed on a patient-derived in vivo GBM model of mTOR kinase inhibitor resistance and coupled it to an analytical approach for detecting changes in signaling coordination to identify actionable alterations in signal coordination that underlie adaptive resistance.

TL;DR: Isolate microfluidicus 1 is, to the authors' knowledge, the first successful example of targeted cultivation of a microorganism from the high-priority group of the Human Microbiome Project’s “Most Wanted” list, and the first cultured representative of a previously unidentified genus of the Ruminococcaceae family.

TL;DR: Although buparlisib achieved significant brain penetration, the lack of clinical efficacy was explained by incomplete blockade of the PI3K pathway in tumor tissue, and integrative results suggest that additional study ofPI3K inhibitors that achieve more-complete pathway inhibition may still be warranted.