Q
Quan Hao
Researcher at University of Hong Kong
Publications - 161
Citations - 7344
Quan Hao is an academic researcher from University of Hong Kong. The author has contributed to research in topics: Anomalous scattering & NAD+ kinase. The author has an hindex of 39, co-authored 159 publications receiving 6311 citations. Previous affiliations of Quan Hao include Daresbury Laboratory & University of Minnesota.
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Journal ArticleDOI
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase.
Jintang Du,Yeyun Zhou,Xiaoyang Su,Jiujiu Yu,Saba Khan,Hong Jiang,Jungwoo Kim,Jimin Woo,Jun Huyn Kim,Brian Hyun Choi,Bin He,Wei Chen,Sheng Zhang,Richard A. Cerione,Johan Auwerx,Quan Hao,Quan Hao,Hening Lin +17 more
TL;DR: It is found that Sirt5 is an efficient protein lysine desuccinylase and demalonylase in vitro and may represent a posttranslational modification that can be reversed by Sirt 5 in vivo.
Journal ArticleDOI
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine
Hong Jiang,Saba Khan,Yi Wang,Guillaume Charron,Bin He,Carlos Sebastian,Jintang Du,Raymond J. Kim,Eva J. Ge,Raul Mostoslavsky,Howard C. Hang,Quan Hao,Hening Lin +12 more
TL;DR: It is shown that human SIRT6 efficiently removes long-chain fatty acyl groups, such as myristoyl, from lysine residues and promotes the secretion of tumour necrosis factor-α (TNF-α) by removing the fatty acy modification on K19 and K20 of TNF- α.
ComponentDOI
Sirt6 Regulates Tnf-Alpha Secretion Through Hydrolysis of Long-Chain Fatty Acyl Lysine
Hong Jiang,Saba Khan,Yi Wang,Guillaume Charron,Bin He,Carlos Sebastian,Jintang Du,Raymond J. Kim,Eva J. Ge,Raul Mostoslavsky,Howard C. Hang,Quan Hao,Hening Lin +12 more
Journal ArticleDOI
Crystal structure of NDM-1 reveals a common β-lactam hydrolysis mechanism
Hongmin Zhang,Quan Hao +1 more
TL;DR: Crystal structure of NDM‐1 reveals a common β‐lactam hydrolysis mechanism applicable to all three subclasses of MBLs, which might help the design of mechanism based inhibitors.
Journal ArticleDOI
Structure of the CED-4–CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans
Nieng Yan,Jijie Chai,Eui Seung Lee,Eui Seung Lee,Lichuan Gu,Qun Liu,Jiaqing He,Jia-Wei Wu,David Kokel,Huilin Li,Quan Hao,Ding Xue,Yigong Shi +12 more
TL;DR: The crystal structure of the CED-4–CED-9 complex is reported at 2.6 Å resolution, and a complete reconstitution of the ced-3 activation pathway is completed using homogeneous proteins of C ED-4, Ced-9 and EGL-1.