Inositol Pyrophosphates Mediate the DNA-PK/ATM-p53 Cell Death Pathway by Regulating CK2 Phosphorylation of Tti1/Tel2
Feng Rao,Jiyoung Y. Cha,Jing Xu,Risheng Xu,M. Scott Vandiver,Richa Tyagi,Robert Tokhunts,Michael A. Koldobskiy,Chenglai Fu,Roxanne K. Barrow,Mingxuan Wu,Dorothea Fiedler,James C. Barrow,Solomon H. Snyder +13 more
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TLDR
It is demonstrated that IP7, formed by IP6K2, binds CK2 to enhance its phosphorylation of the TTT complex, thereby stabilizing DNA-PKcs and ATM and stimulating p53 phosphorylated at serine 15 to activate the cell death program in human cancer cells and in murine B cells.About:
This article is published in Molecular Cell.The article was published on 2014-04-10 and is currently open access. It has received 97 citations till now. The article focuses on the topics: Phosphorylation cascade & Phosphorylation.read more
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Journal ArticleDOI
Regulating tumor suppressor genes: post-translational modifications.
TL;DR: The necessity, characteristics, and mechanisms of each kind of post-translational modification on Rb, p53, PTEN, and its influence on the precise and selective function are reviewed.
Journal ArticleDOI
VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis.
Debabrata Laha,Philipp Johnen,Cristina Azevedo,Marek Dynowski,Michael Weiß,Samanta Capolicchio,Haibin Mao,Tim Iven,Merel Steenbergen,Marc Freyer,Philipp Gaugler,Marília K. F. de Campos,Ning Zheng,Ivo Feussner,Henning J. Jessen,Saskia C. M. Van Wees,Adolfo Saiardi,Gabriel Schaaf +17 more
TL;DR: The inositol pyrophosphate InsP8 plays an important role in plant defenses against herbivorous insects and necrotrophic fungi and is a key cofactor of the jasmonate receptor complex, and it is reported that PPIP5K homologs are widely distributed in plants and that Arabidopsis thaliana VIH1 and VIH2 are functional PPIP 5K enzymes.
Journal ArticleDOI
The "Other" Inositols and Their Phosphates: Synthesis, Biology, and Medicine (with Recent Advances in myo-Inositol Chemistry).
TL;DR: It is timely to consider exploration of the roles and applications of the "other" isomers and their derivatives, likely by exploiting techniques now well developed for the myo series.
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DNA-PKcs promotes alcohol-related liver disease by activating Drp1-related mitochondrial fission and repressing FUNDC1-required mitophagy
TL;DR: The results identified the NR4A1/DNA-PKcs/p53 axis as a novel signaling pathway responsible for ARLD pathogenesis that acts by activating Drp1-related mitochondrial fission and restricting FUNDC1-required mitophagy.
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Role of phosphate sensing in bone and mineral metabolism
Sampada Chande,Clemens Bergwitz +1 more
TL;DR: The metabolic effects of Pi are discussed, which are mediated by Pi transporters, inositol pyrophosphates and SYG1–Pho81–XPR1 (SPX)-domain proteins to maintain cellular phosphate homeostasis in the musculoskeletal system.
References
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WAF1, a potential mediator of p53 tumor suppression
Wafik S. El-Deiry,Takashi Tokino,Victor E. Velculescu,Daniel B. Levy,Ramon Parsons,Jeffrey M. Trent,D Lin,W. Edward Mercer,Kenneth W. Kinzler,Bert Vogelstein +9 more
TL;DR: A gene is identified, named WAF1, whose induction was associated with wild-type but not mutant p53 gene expression in a human brain tumor cell line and that could be an important mediator of p53-dependent tumor growth suppression.
mTOR Signaling in Growth Control and Disease
TL;DR: The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis as mentioned in this paper, and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.
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mTOR signaling in growth control and disease.
TL;DR: Recent advances in understanding of the mTOR pathway are reviewed and pharmacological approaches to treat human pathologies linked to mTOR deregulation are discussed.
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Blinded by the Light: The Growing Complexity of p53
Karen H. Vousden,Carol Prives +1 more
TL;DR: Control of p53's transcriptional activity is crucial for determining which p53 response is activated, a decision that must be understood if the next generation of drugs that selectively activate or inhibit p53 are to be exploited efficiently.
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DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2
TL;DR: Using purified DNA-dependent protein kinase (DNA-PK), it is demonstrated that phosphorylation of p53 at serine 15 and 37 impairs the ability of MDM2 to inhibit p53-dependent transactivation and provides a plausible mechanism by which the induction of p 53 can be modulated by DNA-PK in response to DNA damage.