J
Jo J. Jones
Researcher at GlaxoSmithKline
Publications - 9
Citations - 1407
Jo J. Jones is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Fusion protein & Green fluorescent protein. The author has an hindex of 7, co-authored 9 publications receiving 1247 citations.
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Journal ArticleDOI
Type IIA topoisomerase inhibition by a new class of antibacterial agents.
Benjamin D. Bax,Pan F. Chan,Drake S. Eggleston,Drake S. Eggleston,Andrew P. Fosberry,Daniel R. Gentry,Fabrice Gorrec,Fabrice Gorrec,Ilaria Giordano,Michael M. Hann,Alan Joseph Hennessy,Martin Hibbs,Jianzhong Huang,Emma J. Jones,Jo J. Jones,Kristin K. Brown,Ceri J. Lewis,Earl May,Earl May,Martin R. Saunders,Onkar M. P. Singh,Claus Spitzfaden,Carol Shen,Anthony Shillings,Andrew J. Theobald,Alexandre Wohlkonig,Alexandre Wohlkonig,Neil D. Pearson,Michael N. Gwynn +28 more
TL;DR: This work provides new insights into the mechanism of topoisomerase action and a platform for structure-based drug design of a new class of antibacterial agents against a clinically proven, but conformationally flexible, enzyme class.
Journal ArticleDOI
Crystal structure of human cytochrome P450 2D6.
Paul Rowland,Frank E. Blaney,Martin G. Smyth,Jo J. Jones,Vaughan R. Leydon,Amanda K. Oxbrow,Ceri J. Lewis,Mike Tennant,Sandeep Modi,Drake S. Eggleston,Richard J. Chenery,Angela Bridges +11 more
TL;DR: The crystal structure of human 2D6 helps to explain how Asp-301, Glu-216, and Phe-483 can act as substrate binding residues and suggests that the role of PHe-120 is to control the orientation of the aromatic ring found in most substrates with respect to the heme.
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Purification and Structural Determination of SCB1, a γ-Butyrolactone That Elicits Antibiotic Production in Streptomyces coelicolor A3(2)
Eriko Takano,Takuya Nihira,Yoshitaka Hara,Jo J. Jones,Craig J.L. Gershater,Yasuhiro Yamada,Mervyn J. Bibb +6 more
TL;DR: Bioassays of chemically synthesized SCB1, and of its purified stereoisomers, suggest thatSCB1 acts in a highly specific manner to elicit the production of both actinorhodin and undecylprodigiosin, the two pigmented antibiotics made by S. coelicolor.
Journal ArticleDOI
The structure of ribonuclease P protein from Staphylococcus aureus reveals a unique binding site for single-stranded RNA.
Claus Spitzfaden,Neville Nicholson,Jo J. Jones,Sabine Guth,Ruth V. Lehr,Cathy D Prescott,Lisa A. Hegg,Drake S. Eggleston +7 more
TL;DR: The three-dimensional high-resolution structure of the RNaseP protein from Staphylococcus aureus is determined by nuclear magnetic resonance (NMR) spectroscopy in solution and it is revealed that this protein has an alphabeta-fold, similar to the ribonucleoprotein domain, and a conserved arginine-rich motif does not bind single-stranded RNA.
Journal ArticleDOI
Exploitation of GFP fusion proteins and stress avoidance as a generic strategy for the production of high‐quality recombinant proteins
Yanina R. Sevastsyanovich,Sara Alfasi,Tim W. Overton,Richard M. Hall,Jo J. Jones,Christopher J. Hewitt,Jeffrey A. Cole +6 more
TL;DR: The improved protocol was shown to be suitable for process scale-up and intensification and applicable to the accumulation of an untagged heterologous protein, cytochrome c(2) from Neisseria gonorrhoeae, which requires both secretion and extensive post-translational modification.