J
Jo Spencer
Researcher at King's College London
Publications - 171
Citations - 12045
Jo Spencer is an academic researcher from King's College London. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 48, co-authored 156 publications receiving 11345 citations. Previous affiliations of Jo Spencer include University College London & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
CXCL13, CCL21 and CXCL12 are upregulated in mucosal-associated lymphoid tissue lymphomas in patients with Sjorgen's syndrome and cooperate in the maintenance of the immune response and malignant cell survival
Francesca Barone,Michele Bombardieri,Jo Spencer,P Isaacson,F Humby,Peter Morgan,Stephen Challacombe,Guido Valesini,Costantino Pitzalis +8 more
Posted ContentDOI
Immunogenomic profile of colorectal cancer response to immune checkpoint blockade
Michele Bortolomeazzi,Michele Bortolomeazzi,Mohamed Reda Keddar,Mohamed Reda Keddar,Lucia Montorsi,Lucia Montorsi,Amelia Acha-Sagredo,Amelia Acha-Sagredo,Lorena Benedetti,Lorena Benedetti,Damjan Temelkovski,Damjan Temelkovski,Subin Choi,Subin Choi,Nedyalko Petrov,Katrina Todd,Patty Wai,Jonny Kohl,Tamara Denner,Emma Nye,Robert L. Goldstone,Sophia Ward,Gareth A. Wilson,Maise Al Bakir,Charles Swanton,Susan D. John,James Miles,Banafshé Larijani,Banafshé Larijani,Victoria Kunene,Elisa Fontana,Hendrik-Tobias Arkenau,Hendrik-Tobias Arkenau,Peter J. Parker,Peter J. Parker,Manuel Rodriguez-Justo,Kai-Keen Shiu,Jo Spencer,Francesca D. Ciccarelli,Francesca D. Ciccarelli +39 more
TL;DR: It is proposed that anti-PD1 agents release the PD1-PDL1 interaction between CD8 T cells and macrophages thus promoting cytotoxic anti-tumour activity.
Journal ArticleDOI
Human B cells.
TL;DR: The importance of B cells and their critical role in the maintenance of health through generation of antibody mediated immune protection is undoubted as discussed by the authors, however, the differences between the responses of the B cells with different surface phenotypes in different microanatomical sites as well as diversity in B cell function outside antibody production are still starting to be acknowledged and resolved.
Journal ArticleDOI
B cells in human lymphoid structures
TL;DR: In this paper , the authors consider the zonal structure of lymphoid tissues, the B cell subsets they contain, and how these are regulated, and discuss the impact that methods of deep interrogation have made on our current knowledge base, especially with respect to studies of cells from dissociated tissues.