J
Jo Spencer
Researcher at King's College London
Publications - 171
Citations - 12045
Jo Spencer is an academic researcher from King's College London. The author has contributed to research in topics: B cell & Antibody. The author has an hindex of 48, co-authored 156 publications receiving 11345 citations. Previous affiliations of Jo Spencer include University College London & Guy's and St Thomas' NHS Foundation Trust.
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Journal ArticleDOI
Analysis of TH1 and TH2 cytokine production in low grade B cell gastric MALT-type lymphomas stimulated in vitro with Helicobacter pylori.
TL;DR: There was a dominant TH1-type (pro-inflammatory) response consistent with the TH1 response observed in H pylori gastritis.
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Related IgA1 and IgG producing cells in blood and diseased mucosa in ulcerative colitis.
V C Thoree,S J C Golby,Laurent Boursier,M Hackett,Deborah K. Dunn-Walters,Jeremy D. Sanderson,Jo Spencer +6 more
TL;DR: The clonal distribution and characteristics of IgG and related IgA in the mucosa and blood of patients with UC suggest a peripheral response is expressed and expanded in the colonic mucosa, and it is shown that JH1 usage was characteristic of the peripheral repertoire.
Journal ArticleDOI
Immunohistochemical analysis of ageing human B and T cell populations reveals an age-related decline of CD8 T cells in spleen but not gut-associated lymphoid tissue (GALT).
TL;DR: Differences were seen between T cell populations in the T cell zones and those in B cell areas, and different compartments within each tissue, which may be of importance in future studies of the ageing immune system.
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Phenotypic Characterization of CD3−7+ Cells in Developing Human Intestine and an Analysis of Their Ability to Differentiate into T Cells
Ute Günther,Judith A. Holloway,John Gordon,Andrea Knight,Victoria Chance,Neil A. Hanley,David I. Wilson,Ruth R. French,Jo Spencer,Howard W. Steer,Graham Anderson,Thomas T. MacDonald +11 more
TL;DR: It is demonstrated that the CD3−7+ cells present in the human fetal gut display a distinct phenotype and are able to develop into CD3+ T cells.
Journal ArticleDOI
Interleukin-10 and prostaglandin E2 have complementary but distinct suppressive effects on Toll-like receptor-mediated dendritic cell activation in ovarian carcinoma.
Eva Brencicova,Ann L. Jagger,Hayley G. Evans,Mirella Georgouli,Alex Laios,Steve Attard Montalto,Gautam Mehra,Jo Spencer,Ahmed Ashour Ahmed,Shanti Raju-Kankipati,Leonie S. Taams,Sandra S. Diebold +11 more
TL;DR: This study identifies IL-10 and prostaglandin E2 (PGE2) as the pivotal immunosuppressive components in OC-associated ascites compromising TLR-mediated DC activation and highlights PGE2 a potentially important target for immunotherapy in OC.