Jo Spencer

TL;DR: It is suggested that low‐grade MALT lymphomas may migrate beyond the primary tumour site, but that tumour cells distant to the primary site may differentiate into mature, non‐dividing plasma cells.

TL;DR: Overall, this study suggested that human peritoneal B cell are either peripheral or mixed in origin; they are unlikely to represent an inductive compartment for the mucosal B cell system.

TL;DR: It is shown here that the motifs surrounding the different substitutions from A vary significantly; there is no single targeting motif for all A mutations, and WA and TW should not be considered as reverse complement hot spot motifs for A and T mutations.

TL;DR: In this article, a bifurcation of human B cell maturation from the T1 stage forming IgMhi and IgMlo developmental trajectories was identified by pseudotime analysis of scRNA-sequencing data.

TL;DR: It is investigated the load and distribution of mutations in one group of lymphomas--marginal zone B-cell lymphomas of mucosa-associated lymphoid tissues (MALT-type lymphoma), which are dependent on Helicobacter pylori for disease progression, and feels that there is selection to conserve antibody structure and that this does not reflect selection for antigen.